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群馬大学 生体調節研究所

アクセス アクセス

発表論文

代謝シグナル解析分野(北村忠弘)

No. Year Title Author Corresponding Journal Vol. Pages
1 2013 A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells. Masubuchi Y, Nakagawa Y, Ma J, Sasaki T, Kitamura T, Yamamoto Y, Kurose H, Kojima I, Shibata H Shibata H PLoS ONE 8 e54500
2 2013 Hypothalamic ATF3 is involved in regulating glucose and energy metabolism. Lee Y-S, Sasaki T, Kobayashi M, Kikuchi O, Kim H-J, Yokota-Hashimoto H, Shimpuku M, Susanti V-Y, Ido-Kitamura Y, Kimura K, Inoue H, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ohya S, Tanaka Y, Kitajima S and Kitamura T Kitamura T Diabetologia 56 1383-1393
3 2013 Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates. Sasaki T, Shimpuku M, Kitazumi T, Hiraga H, Nakagawa Y, Shibata H, Okamatsu-Ogura Y, Kikuchi O, Kim HJ, Fujita Y, Maruyama J, Susanti VY, Yokota-Hashimoto H, Kobayashi M, Saito M, Kitamura T. Kitamura T Endocr J 60 1117-1129
4 2013 The role of FOXO1 in b-cell failure and type 2 diabetes mellitus. Kitamura T Kitamura T Nat Rev Endocrinology 9 615-623
5 2013 Protective effects of a nicotinamide derivative, isonicotinamide, against streptozotocin-induced beta-cell damage and diabetes in mice. Fukaya M, Tamura Y, Chiba Y, Tanioka T, Mao J, Inoue Y, Yamada M, Waeber C, Ido-Kitamura Y, Kitamura T, Kaneki M Kaneki M Biochem Bioph Res Co 442 92-98
6 2013 A critical role of fatty acid binding protein 4 and 5 (FABP4|5) in the systemic response to fasting. Syamsunarno MA, Iso T, Hanaoka Y, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, Tsushima Y, Endo K, Hotamisligil GS, Kurabayashi M Iso T PloS ONE 8 e79386
7 2014 ATF3 expression is induced by low glucose in pancreatic alpha and beta cells and regulates glucagon but not insulin gene transcription. Lee Y-S, Kobayashi M, Kikuchi O, Sasaki T, Kim H-J, Yokota-Hashimoto H, Susanti V-Y, Ido-Kitamura Y and Kitamura T Kitamura T Endocr J 61 85-90
8 2014 Hypothalamic Sirt1 prevents age-associated weight gain byimproving leptin sensitivity in mice. Sasaki T, Kikuchi O, Shimpuku M, Susanti V-Y, Yokota-Hashimoto H, Taguchi R, Shibusawa N, Sato T, Tang L, AmanoK, Kitazumi T, Kuroko M, Fujita Y, Maruyama J, Lee Y-S,Kobayashi M, Nakagawa T, Minokoshi Y, Harada A, Yamada Mand Kitamura T Kitamura T Diabetologia 57 819-831
9 2014 TCF7L2 in pancreatic beta cells plays crucial roles in glucosehomeostasis by regulating beta-cell mass. Takamoto I, Kubota N, Nakaya K, Kumagai K, Hashimoto S,Kubota T, Inoue M, Kajiwara E, Katsuyama H, Obata A, SakuraiY, Iwamoto M, Kitamura T, Ueki K and Kadowaki T Kadowaki T Diabetologia 57 542-553
10 2014 Elevated mitochondrial biogenesis in skeletal muscle is associated with testosterone-induced body weight loss in male mice. Usui T, Kajita K, Kajita T, Mori I, Hanamoto T, Ikeda T, Okada H, Taguchi K, Kitada Y, Morita H, Sasaki T, Kitamura T, Sato T, Kojima I, Ishizuka T. Kajita K FEBS Lett 588 1935-1941
11 2014 Sirt1 reverses the obesity by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice. Susanti V-Y, Sasaki T, Yokota-Hashimoto H, Matsui S, Lee Y-S, Kikuchi O, Shimpuku M, Kim H-J, Kobayashi M and Kitamura T Sasaki T, Kitamura T Obesity 10 2115-2119
12 2014 Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor. Yoshino S, Satoh T, Yamada M, Hashimoto K, Tomaru T, Katano-Toki A, Kakizaki S, Okada S, Shimizu H, Ozawa A, Tuchiya T, Ikota H, Nakazato Y, Mori M, Matozaki T, Sasaki T, Kitamura T, Mori M Satoh T Endocrinology 155 3459-3472
13 2014 Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis. Kohno D, Lee S, Harper MJ, Kim KW, Sone H, Sasaki T, Kitamura T, Fan G, Elmquist JK Elmquist JK J Neuroscience 34 15288-15296
14 2015 A mutant allele encoding DNA-binding-deficient Foxo1 differentially regulates hepatic glucose and lipid metabolism. Cook JR, Matsumoto M, Banks AS, Kitamura T, Tsuchiya K, Accili D Accili D Diabetes  64 1951-1965
15 2015 Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue. Sasaki T, Hiraga H, Yokota-Hashimoto H, Kitamura T Kitamura T Endocr J 62 469-473
16 2015 Overexpression of insulin receptor partially improves obese and diabetic phenotype in db/db mice. Sasaki T, Kuroko M, Sekine S, Matsui S, Kikuchi O, Susanti VY, Kobayashi M, Tanaka Y, Yuasa T, Kitamura T Kitamura T Endocr J 62 787-796
17 2015 N-methyl D-aspartate receptor co-agonist D-serine suppresses intake of high-preference food. Sasaki T, Kinoshita Y, Matsui S, Kakuta S, Yokota-Hashimoto H, Kinoshita K, Iwasaki Y, Kinoshita T, Yada T, Amano N, Kitamura T Sasaki T Am J Physiol Regul Integr Comp Physiol 309 R561-575
18 2016 Increased glucose-induced secretion of glucagon-like peptide-1 in mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2. Ghanem S, Heinrich G, Lester S, Pfeiffer V, Bhattacharya S, Patel P, DeAngelis A, Dai T, Ramakrishnan S, Smiley Z, Jung D, Lee Y, Kitamura T, Ergun S, Kulkarni R, Kim J, Giovannucci D, Najjar S Najjar S J Biol Chem 291 980-988
19 2016 Control of appetite and food preference by NMDA receptor and its co-agonist D-serine. Sasaki T, Matsui S, Kitamura T Sasaki T Int J Mol Sci 17 e1081
20 2016 Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells. Kunii M, Ohara-Imaizumi, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M, Ohmuraya M, Sato T, Yoshimura S, Sato K, Harada R, Kim Y-J, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, Harada A Harada A  J Cell Biol  215 121-138
21 2016 DNA methylation suppresses leptin gene in 3T3-L1 adipocytes.  Kuroda M, Tominaga A, Nakagawa K, Nishiguchi M, Sebe M, Miyatake Y, Kitamura T, Tsutsumi R, Harada N, Nakaya Y, Sakaue H  Sakaue H  PLoS ONE  11  e0160532
22 2017  Intracerebroventricular injection of ghrelin decreases wheel running activity in rats.  Miyatake Y, Shiuchi T, Mawatari K, Toda S, Taniguchi Y, Futami A, Sato F, Kuroda M, Sebe M, Tsutsumi R, Harada N, Minokoshi Y, Kitamura T, Gotoh K, Ueno M, Nakaya Y, Sakaue H  Sakaue H  Peptides  87  012-19
23 2016  Sweet taste receptor serves to activate glucose- and leptin-responsive neurons in the hypothalamus arcuate nucleus and participates in glucose responsiveness.  Kohno D, Koike M, Ninomiya Y, Kojima I, Kitamura T, Yada T  Kohno D  Front Neurosci  10  502
24 2017 Accurate analytical method for human plasma glucagon levels using liquid chromatography-high resolution mass spectrometry: Comparison with commercially available immunoassays Miyachi A, Kobayashi M, Mieno E, Goto M, Furusawa K, Inagaki T, Kitamura T Kitamura T Anal Bioanal Chem 409 5911-5918
25 2017 Intraperitoneal injection of D-serine suppresses high-fat diet intake and preference in male mice Sasaki T, Yoshimasa Y, Matsui S, Yokota-Hashimoto H, Kobayashi M, Kitamura T Sasaki T Appetite 118 120-128
26 2017 A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test Emoto R, Kurosawa A, Nikaido Y, Mashiko M, Saheki T, Nakajima N, Kuroiwa S, Otobe M, Ohsaki M, Tooyama K, Inoue Y, Kuwabara N, Kikuchi O, Kitamura T, Kojima I, Nakagawa Y, Saito T, Osada H, Futahashi M, Sezutsu H, Takeda S Takeda S Euro J Pharma 814 130-137
27 2017 Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y Fujitani Y PLoS Genet 13 e1006950
28 2018 The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic beta vells Torii S, Kubota C, Saito N, Kawano A, Hou N, Kobayashi M, Torii R, Hosaka M, Kitamura T, Takeuchi T, Gomi H Torii S J Biol Chem 293 5920-5933
29 2018 ChREBP-knockout mice show sucrose intolerance and fructose malabsorption Kato T, Iizuka K, Takao K, Horikawa Y, Kitamura T, Takeda J Iizuka K Nutrients 10 E340
30 2018 A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice Sasaki T, Numano R, Yokota-Hashimoto H, Matsui S, Kimura N, Takeuchi H, Kitamura T Sasaki T Mol Brain 11 28
31 2018 Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance Gulshan M, Yaku K, Okabe K, Mahmood A, Sasaki T, Yamamoto M, Hikosaka K, Usui I, Kitamura T, Tobe K, Nakagawa T Nakagawa T Aging Cell 17 e12798
32 2018 Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signaling in mice Matsui S, Sasaki T, Kohno D, Yaku K, Inutsuka A, Yokota-Hashimoto H, Kikuchi O, Suga T, Kobayashi M, Yamanaka A, Harada A, Nakagawa T, Onaka T, Kitamura T Sasaki T Nat Communi 9 4604-4620
33 2019 SGLT1 in pancreastic a cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels Suga T, Kikuchi O, Kobayashi M, Matsui S, Yokota-Hashimoto H, Wada E, Kohno D, Sasaki T, Takeuchi K, Kakizaki S, Yamada M, Kitamura T Kitamura T Mol Metab 19 1-12
34 2019 Cell autonomous dysfunction and insulin resistance in pancreatic alpha cells. Honzawa N, Fujimoto K, Kitamura T Fujimoto K Int Mol Sci 20 E3699
35 2019 Basal glucagon hypersecretion and response to oral glucose load in prediabetes and mild type 2 diabetes. Ichikawa R, Takanao K, Fujimoto K, Motomiya T, Kobayashi M, Kitamura T, Shichiri M Takanao K Endocr J 66 663-675
36 2019 Heapatic gluconeogenic response to single and long-term SGLT2 inhibition in lean/obese male hepatic G6pc-reporter mice. Inaba Y, Hashiguchi E, Watanabe H, Kimura K, Sato M, Kobayashi M, Matsumoto M, Kitamura T, Kasuga M, Inoue H Inaba Y Endocrinology 160 2811-2824
37 2020 FCoR-Foxo1 Axis Regulates a-cell Mass through Repression of Arx Expression. Kodani N, Nakae J, Kobayashi M, Kikuchi O, Kitamura T, Itoh H Nakae J iScience 23 100798
38 2020 DNA methylation status influences insulin-induced glucose transport in 3T3-L1 adipocytes by mediating p53 expression. Kuroda M, Onoyama R, Sasaki W, Sebe M, Kitamura T, Masumoto S, Tsutsumi R, Harada N, Sakaue H Sakaue H Biochem Bioph Res Co    
39 2020 Anagliptin suppresses diet-induced obesity through enhancing leptin sensitivity and ameliorating hyperphagia in high-fat high-sucrose diet fed mice. Kohno D, Furusawa K, Kitamura T Takanao K Endocr J 67 523-529
40 2020 The PDK1-Foxo1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotrien B4 axis Hosooka T, Hosokawa Y, Matsugi K, Shinohara M, Senga Y, Tamori Y, Aoki C, Matsui S, Sasaki T, Kitamura T, Kuroda M, Sakaue H, Nomura K, Yoshino K, Nabatame Y, Itoh Y, Yamaguchi K, Hayashi Y, Nakae J, Accili D, Yokomizo T, Seino S, Kasuga M, Ogawa W Ogawa W Proc Natl Acad Sci U S A 117 11674-11684
41 2020 Plasma glucagon levels measured by sandwich ELISA are correlated with impaired glucose tolerance in type 2 diabetes Kobayashi M, Satoh H, Matsuo T, Kusunoki Y, Tokushima M, Watada H, Namba M, Kitamura T Kitamura T Endocr J 67 903-922
42 2020 FOXO1 suppresses PGC-1β gene expression in skeletal muscles Nakai S, Oyabu M, Hatazawa Y, Akashi S, Kitamura T, Miura S, Kamei Y Kamei Y FEBS Open Bio 10 1373-1388
43 2020 Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling Suga T, Sato K, Ohyama T, Matsui S, Kobayashi T, Tojima H, Horiguchi N, Yamazaki Y, Kakizaki S, Nishikido A, Okamura T, Yamada M, Kitamura T, Uraoka T Uraoka T World J of Hepatol 12 350-362
44 2020 HNF1a controls glucagon secretion in pancreatic alpha cells through modulation of SGLT1 Sato Y, Rahman M.M, Haneda M, Tsuyama T, Mizumoto T, Yoshizawa T, Kitamura T, Gonzalez F.J, Yamamura K, Yamagata K Yamagata K Biochim Biophys Acta Mol Basis Dis 1866 165898
45 2020 Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis Uzawa H, Kohno D, Koga T, Sasaki T, Fukunaka A, Okuno T, Watanabe A.J, Kazuno S, Miyatsuka T, Kitamira T, Fujitani Y, Watada H, Saeki K * and Yokomizo T Saeki K FASEB 34 13949-13958
46 2021 Effects of the once-weekly DPP4 inhibitor Omarigliptin on glycemic control in patients with type 2 siabetes mellitus on maintenance hemodialysis: a 24-week open-label, multicenter randomized controlled study Yoshizawa Y, Hosojima M, Kabasawa H, Tanabe N, Ugamura D, Koda Y, Shimada H, Takasawa T, Ito T, Kitamura T, Kobayashi M, Suzuki Y, Narita I, Saito A Hosojima M Diabetes Ther 12 655-667
47 2021 Pseudo-hyperglucagonemia was observed in the pancreatectomized cases when measured by glucagon sandwich ELISA Kobayashi M, Waki H, Nakayama H, Miyachi A, Mieno E, Hamajima H, Goto M, Yamada K, Yamauchi T, Kadowaki T, Kitamura T Kitamura T J Diabetes Investig 12 286-289
48 2021 Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load Kuramoto N, Nomura K, Kohno D, Kitamura T, Karsenty G, Hosooka T, Ogawa W Ogawa W Sci Rep 11 3447
49

2021

 

Measurement of plasma glucagon levels using mass spectrometry in patients of type 2 diabetes on maintenance hemodialysis. Yoshizawa Y, Hosojima M, Kabasawa H, Tanabe N, Miyachi A, Hamajima H, Mieno E, Kobayashi M, Kitamura T, Narita I, Saito A Hosojima M Kidney & Blood Pressure Research 46 652-656
50 2021 Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model. Morio A, Tsutsumi R, Satomi S, Kondo T, Miyoshi H, Kato T, Kuroda M, Kitamura T, Hara K, Saeki N, Sakaue H, Tsutsumi Y-M Tsutsumi Y-M Diabetol & Metabolic Syndrome 13 139
51 2021 Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling. Morio A, Tsutsumi R, Kondo T, Miyachi H, Kato T, Narasaki S, Satomi S, Nakaya E, Kuroda M, Sakaue H, Kitamura T, Tsutsumi YM. Tsutsumi Y-M Nutri Metab and Cardiovas Diseases 31 2979-2986
52 2021 Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice. Wada E, Kobayashi M, Kohno D, Kikuchi O, Suga T, Matsui S, Yokota-Hashimoto H, Honzawa N, Ikeuchi Y, Tsuneoka H, Hirano T, Obinata H, Sasaki T, Kitamura T. Kitamura T J Nutri Biochem 97 108811
53 2022 The hypothalamic paraventricular 1 nucleus is the center of the hypothalamo-pituitary-thyroid axis for regulating thyroid hormone levels. Kondo Y, Ozawa A, Kohno D, Saito K, Buyandalai B, Yamada S, Horiguchi K, Nakajima Y, Shibusawa N, Harada A, Yokoo H, Akiyama H, Sasaki T, Kitamura T, Yamada M. Yamada M Thyroid 32 105-114
54 2022 Effects of a new 75 g glucose- and high fat-containing cookie meal test on postprandial glucose and triglyceride excursions in morbidly obese patients. Yamamoto Y, Ozamoto Y, Kobayashi M, Tezuka Y, Azuma C, Sekine O, Ito-Kobayashi J, Washiyama M, Oe Y, Iwanishi M, Togawa T, Hagiwara A, Kitamura T, Shimatsu A and Kashiwagi A. Kashiwagi A Endocri J 69 689-703

 

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