令和7年度(2025年4月1日~2026年3月31日)
- Takaine M, Morita R, Yoshinar Yi, Nishimura T. (2025/4/10) Phase separation of the PRPP amidotransferase into dynamic condensates promotes de novo purine synthesis in yeast. PLoS Biol, 23(4):e3003111.
[PubMed]
- Asakura J, Nagao M, Shinohara M, Hosooka T, Kuwahara N, Nishimori M, Tanaka H, Satomi-Kobayashi S, Matsui S, Sasaki T, Kitamura T, Otake H, Ishiba T, Ogawa W, Hirata K, Toh R. (2025/4/16) Impaired cardiac branched-chain amino acid metabolism in a novel model of diabetic cardiomyopathy. Cardiovasc Diabetol
, 24(1):167. [PubMed]
- Matsumoto E, Sasaki T, Higashiyama T, Sasaki N.(2025/4/21) Human RCC1L is involved in the maintenance of mitochondrial nucleoids and mtDNA. Sci Rep, 15(1):13811. [PubMed]
- Nishio M, Yamaguchi K, Otani J, Yuguchi K, Kohno D, Sasaki T, Kitamura T, Shinohara M, Soga T, Kawamura K, Sasaki A, Oshima M, Hikasa H, Woo M, Sasaki T, Nishina H, Nakao K, Maehara T, Suzuki A. (2025/4/29) MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes. Proc Natl Acad Sci U S A, 122(17). [PubMed]
- Hattori N, Takamatsu H, Iida N, Asano N, Yamashita S, Oba GM, Kimura K, Yoshida A, Kobayashi E, Nakayama R, Matsumoto M, Nakamura M, Kawai A, Ushijima T. (2025/4/30) Epigenetic disruption of adipogenic gene enhancers in dedifferentiated liposarcomas and its therapeutic value. Front Oncol, 15:1419877. [PubMed]
- Aoki-Saito H, Mandai H, Nakakura T, Sasaki T, Kitamura T, Omori K, Hisada T, Okada D, Suga S, Yamada M, Saito T. (2025/5 ) (+)-Terrein exerts anti-obesity and anti-diabetic effects by regulating the differentiation and thermogenesis of brown adipocytes in mice fed a high-fat diet. Biomed Pharmacother
, 186:118030. [PubMed]
- Masuda M, Komatsu T, Atia S, Suzuki T, Hayashi M, Toyoda A, Kimura H, Inagaki T. (2025/5) Iron-dependent JMJD1A-mediated demethylation of H3K9me2 regulates gene expression during adipogenesis in a spatial genome organization-dependent manner. Genes Cells, 30(3):e70023. [PubMed]
- Miyauchi E, Yamazaki K, Tsuboi Y, Nakajima T, Ono S, Mizuno K, Takahashi N, Imamura K, Morita H, Miura N, Okuda S, Kikuchi J, Sasaki N, Ohno H, Yamazaki K. (2025/5/8) Patients with periodontitis exhibit persistent dysbiosis of the gut microbiota and distinct serum metabolome. J Oral Microbiol, 17(1):2499284. [PubMed]
- Kobayashi R, Hatada I. (2025/6) Understanding epigenetic regulation in the endometrium – lessons from mouse models with implantation defects. Epigenomics, 17(8):541-554. [PubMed]
- Sugiura K, Atsushi C. Suzuki. (2025/7) Milnesium (Tardigrada: Apochela) having elongated buccal tube from Mt. Yukikuradake (Toyama and Niigata prefecture, Japan). Zoologischer Anzeiger. 317:165-175.
- Sen A, Imai A, Miyauchi E, Yanagisawa K, Oda T, Sasaki F, Uchida S, Okada T, Yokobori T, Saeki H, Odamaki T, Sasaki N. (2025/7/1) Comprehensive gene expression analysis of organoid-derived healthy human colonic epithelium and cancer cell line stimulated with live probiotic bacteria. Sci Rep, 15(1):22325. [PubMed]
- Yamamoto Y, Kobayashi M, Togawa T, Sekine O, Ozamoto Y, Fuse J, Ito-Kobayashi J, Oe Y, Hagiwara A, Iwanishi M, Shimatsu A, Kitamura T, Kashiwagi A. (2025/7/1) Yamamoto Y, Kobayashi M, Togawa T, Sekine O, Ozamoto Y, Fuse J, Ito-Kobayashi J, Oe Y, Hagiwara A, Iwanishi M, Shimatsu A, Kitamura T, Kashiwagi A. Gut hormone secretions in a meal tolerance test on insulin, glucagon, and glycemic excursions in patients with morbid obesity undergone sleeve gastrectomy. Am J Physiol Endocrinol, 329(1):E25-E38 Metab. [PubMed]
- Kato K, Nishio Y, McMillan KJ,Al-Maraghi A , Kroes HY, Abdel-Hamid MS, Jones E,Shaw S, Yoshida A, Otsuji S, Murofushi Y, Aamer W, Bhat AA, AlRayahi J, Al-Shabeeb Akil AS, Aliyev E, van Binsbergen E, Janssen EJ , Mehrin KM, Oishi H, Kobayashi R, Horii T, Hatada I, Saito A, Hattori M, Kawano Y, Lewis PA, Heesom KJ, Takarada T, Sawamoto K, Matsushita M, Ogi T, Butkovic R, Danson C, Wilkinson KA, Fakhro KA, Zaki MS, Saitoh S, Cullen PJ. (2025/7/2) Ritscher-Schinzel syndrome can be characterized as an endosomal recyclinopathy. Sci Transl Med, 17(805):eadt2426. [PubMed]
- Takada Y, Ichinose T, Fuse N, Saito K, Ikeda-Ohtsubo W, Tanimoto H, Hori M. (2025/7/7) Gut microbiota-mediated lipid accumulation as a driver of evolutionary adaptation to blue light toxicity in Drosophila. Commun Biol, 8(1):998. [PubMed]
- Fukunaka A, Fujitani Y. (2025/7/9) Role of zinc homeostasis in the pathophysiology of Diabetes (Chapter 13) . Coordination Chemistry Perspectives Edited by Hiroyuki Yasui; Taiho Kambe, 2:214-228.
- Tsuno T, Li J, Nishiyama K, Kawasawa YI, Inoue R, Ong Yajima E, Nishiyama A, G Yabe S, Kin T, Okochi H, Tamura T, Shapiro AMJ, Oyadomari S, Kitamura T, Terauchi Y, Shirakawa J. (2025/7/25) Imeglimin suppresses glucagon secretion and induces a loss of α-cell identity. Cell Rep Med, 6(8):102254. [PubMed]
- Nameki N, Tomisawa C, Hoshino S, Shimizu H, Abe M, Arai S, Kuwasako K, Asakawa N, Inoue Y, Horii T, Hatada I, Watanabe M. (2025/8) Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor’s loss. FEBS Open Bio
, 15(8):1303-1318. [PubMed]
- Kikuchi S, Torii S, Hosaka M, Yasui T, Gomi H. (2025/8) Expression Diversity in Endocrine Cells and Between Species Revealed by Novel Synthetic Peptide Antibodies Recognizing the Neuroendocrine Protein 7B2. J Histochem Cytochem, 73(7-8):289-314. [PubMed]
- Takeuchi T, Miyauch E, Nakanishi Y,Ito Y, Kato T, Yaguchi K, Kawasumi M, Tachibana N, Ito A, Shimamoto S, Matsuyama A, Sasaki N, Kimura I, Ohno H. (2025/8/5) Acetylated cellulose suppresses body mass gain through gut commensals consuming host-accessible carbohydrates. Cell Metab, 37(8):1682-1697. [PubMed]
- Ohashi K, Kroon GJ, Otomo T. (2025/8/5) Structural Insights into the GABARAP–ATG3 Backside Interaction and Apo ATG3 Conformation. Biochemistry, 64(15):3178-3189. [PubMed]
- Yang C, Arai M, Ariyanto EF, Zhang J, Lubis DM, Ito R, Xie S, Nitta M, Kawashima F, Ishitsuka T, Yang C, Suzuki T, Komatsu T, Sagae H, Jin H, Takahashi H, Kobayashi E, Wei Y, Liu B, Choi H, Wada Y, Tanaka T, Osawa T, Kimura H, Kodama T, Aburatani H, Tachibana M, Shinkai Y, Inagaki T. Soga T, Osborne TF, Yoneshiro T, Matsumura Y, Sakai J. (2025/8/26) Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling. Cell Rep, 44(8):116060. [PubMed]
- Shimba A, Cui G, Abe S, Hirota K, Miyauchi E, Takami D, Tani-Ichi S, Kato R, Tajima M, Kanahashi T, Miyazaki M, Rodewald HR, Yoshitomi H, Ueno H, Ohno H, Ikuta K. (2025/8/26) Stress-induced glucocorticoids enhance acute inflammation by promoting the differentiation of Th17 cells. Cell Rep, 44(8):116093. [PubMed]
- Hattori N, Ushijima T. (2025/8/29) Epigenetics Methods, 2nd Edition: Chapter Two – Principles of bisulfite conversion of DNA and methylation-specific PCR in biological research. Epigenetics Methods, 2:17-31
- Kohno D, Kawabata-Iwakawa R, Ichinose S, Suyama S, Ohashi K, Ariyani W, Sadakata T, Yokota-Hashimoto H, Kobayashi R, Horii T, Susanti VY, Konno A, Tsuneoka H, Yoshikawa C, Matsui S, Harada A, Yada T, Hatada I, Hirai H, Nishiyama M, Sasaki T, Kitamura T. (2025/9) FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons. EMBO J, 44(18):4919-4961. [PubMed]
- Inoue R, Tsuno T, Nishimura T, Fukushima S, Hirai S, Shimoda M, Yoshinari Y, Sakai C, Kin T, Lim EXH, Teo AKK, Matsumoto S, Shapiro AMJ, Shirakawa J. (2025/9/1) Adenylosuccinate mediates imeglimin-induced proliferative and antiapoptotic effects in β-cells. Diabetes, 74(9):1589-1602. [PubMed]
- Yabe SG, Nishida J, Fukuda S, Kin T, Nishiyama A, Tamura T, Takeda F, Tamura-Nakano M, Shirakawa J, Okochi H. (2025/9/10) High glucose burden disrupts the glucose responsiveness of human pancreatic beta cells encapsulated in alginate fibers during Long-Term culture. Gene, 964:149639. [PubMed]
- Nakagawa Y, Horii T, Fukunaka A, Sato T, Zhang Z, Kobayashi M, Kitamura T, Hayashi Y, Nishimura T, Hatada I, Fujitani Y. (2025/9/23) Liver-specific glucagon dysfunction promotes PP-cell hyperplasia and formation of glucagon and PP double-positive cells. PLoS One, 20(9):e0329094. [PubMed]
- Uchida S, Yokobori T, Yanagisawa K, Erkhem-Ochir B, Dorjkhorloo G, Okami H, Katayama C, Shibasaki Y, Nakazawa N, Komine C, Shiraishi T, Okada T, Osone K, Kimura A, Sano A, Sakai M, Sasaki N, Shirabe K, Saeki H. (2025/10) Intratumoral Lipopolysaccharide Positivity Related to Tumor-Associated Macrophage Infiltration and Poor Prognosis in Esophageal Squamous Cell Carcinoma. Ann Surg Oncol, 32(10):8013-8023. [PubMed]
- Sakil MA, Angon PB, Polash MAS, Mondal S, Zannat M, Islam MS, Norizuki T, Ueda T. (2025/10/22) Autophagic cell death in plants. Plant Cell Physiol, 66(10):1389-1396. [PubMed]
- Matsuzaki M, Imai A, Yanagisawa K, Oda T, Satsu H, Sasaki N, Miyauchi E. (2025/10/24) Mucin-dependent transcriptional dynamics of Akkermansia muciniphila in co-culture with human colonic organoids. Biosci Biotechnol Biochem, 89(11):1649-1657. [PubMed]
- Nishimura T, Yoshinari Y. (2025/11/1) Carbohydrate and protein metabolism. 1:275-323.
- Shirakawa J. (2025/11/12) The insulin/IGF receptor puzzle in pancreatic β-cell recovery: A missing link for diabetes therapy?. J Biochem, 179(4):205-211. [PubMed]
- Endo Y, Sugino RP, Takenobu H, Mukae K, Okada R, Shinno Y, Haruta M, Satoh S, Akter J, Hattori N, Nakazawa A, Ushijima T, Nakagawara A, Ohira M, Nio M, Kamijo T. (2025/11/12) Synthetic lethality of EZH2 and DNMT inhibition suppresses neuroblastoma proliferation via MYCN destabilization. BMC Cancer, 25(1):1759. [PubMed]
- Ikeda T, Masujima Y, Watanabe K, Nishida A, Yamano M, Igarashi M, Sasaki N, Katoh H, Kimura I. (2025/12) The free fatty acid receptor GPR164 maintains intestinal homeostasis and barrier function. EMBO Rep, 26(23):5905-5930. [PubMed]
- Norizuki T, Kushida Y, Sekimoto T, Sasaki T, Yamano K, Matsuda N, Sasaki R, Noda NN, Sato K, Sato M. (2025/12/15) ALLO-1a is a ubiquitin-binding adaptor for allophagy in Caenorhabditis elegans. J Cell Sci, 138(24):jcs264252. [PubMed]
- Sato K, Mogi C, Aoki-Saito H, Ishizuka T, Shirakawa J, Tomura H, Im DS. (2025/12) The proton-sensing OGR1 receptor and hypoxia-inducible factors promote metal ion-induced inflammatory responses in coronary artery smooth muscle cells. J Biol Chem, 301(12):110842. [PubMed]
- Shirakawa J, De Jesus DF, Tsuno T, Basile G, Inoue R, Takatani T, Nishiyama A, Okawa ER, Tamura T, Terauchi Y, Kulkarni RN. (2025/12/1) Regulatory roles of IGF2R in insulin secretion and adaptive β-cell proliferation. Diabetes, 74(12):2351-2364. [PubMed]
- Miyauchi E, Yamaoka M, Kamimura I, Mizuta M, Takenaka M, Akiyama U, Kawasumi M, Sasaki N, Ohno H, Ando S, Ymasaki S, Nishida A, Mogi K, Nagasawa M, Kikusui T. (2025/12/3) Dog ownership during adolescence alters the microbiota and improves mental health. iScience, 28(12):113948. [PubMed]
- Hashimoto-Sugimoto M, Norizuki T, Segami S, Ohta Y, Suetsugu N, Ueda T, Morita MT. (2025/12/4) Amyloplasts are necessary for full gravitropism in thallus of Marchantia polymorpha. J Exp Bot, 6(22):6741-6757. [PubMed]
- Miyauchi E, Taida T, Uchiyama K, Nakanishi Y, Kato T, Koido S, Sasaki N, Ohkusa T, Sato N, Ohno H. (2025/12/5) Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota. Gut, 75(1):46-56. [PubMed]
- Horii T, Morita S, Hino S, Hino Y, Fukushima HS, Kobayashi R, Kimura M, Nakao M, Mizukami Y, Inoue A, Hatada I. (2025/12/25) Germline epigenome editing identifies H3K9me3 as a mediator of intergenerational DNA methylation recovery in mice. Nat Commun, 16(1):11200. [PubMed]
- Shirakawa J. (2026/1) Gαs defines the fundamental coupling mechanism of insulin secretion. J Diabetes Investig, 17(1):9-11. [PubMed]
- Kurobe-Takashima Y, Yanagisawa K, Saito Y, Miyawaki R, Misaka T, Mizoi J, Miyauchi E, Sasaki N, Ogihara T, Kobayashi S. (2026/1/23) Contribution of organic anion transporting polypeptides to bile acid uptake in the Caco-2 cell monolayer and gastrointestinal tract. J Biol Chem, 302(3):111205. [PubMed]
- Li J, Zhang R, Zeng X, Xu W, Gao L, He S, Wu B, Ma Y, Nie Y, Shirakawa J, Xia H, Li W. (2026/2) Imeglimin ameliorates MASLD by targeting PEN2 to activate AMPK pathway. Metabolism, 175:156458. [PubMed]
- Fujimoto K, Honda-Kitahara M, Hattori N, Matsushita Y, Hibiya Y, Satomi K, Matsunaga H, Tsutsumi S, Okamoto A, Inoue T, Yamada M, Watanabe M, Wakimoto H, Onuki R, Kato M, Sato TA, Ushijima T, Kitabayashi I, Ichimura K. (2026/2/12) Long-term administration of the mutant IDH inhibitor DS-1001b suppresses the growth of IDH1-mutant glioma in vitro and in mouse xenograft models and alters epigenetic profiles. Acta Neuropathol, 151(1):15. [PubMed]
- Okano S, Yoshizawa Y, Nobuchi S, Takeda Y, Miyazaki K, Akashi H, Toyota K, Yamagishi G, Miyagawa S. (2026/2/18) Gonadal development and gene expression in the leopard gecko during temperature-dependent sex determination. Dev Biol, 533:121-132. [PubMed]
- Suga T, Tabei Y, Kikuchi O, Kohno D, Ikeuchi Y, Kobayashi M, Nakagawa Y, Tojima H, Yamazaki Y, Sato K, Kakizaki S, Nishimura T, Fujitani Y, Takizawa T, Uraoka T, Kitamura T. (2026/3) Sodium-glucose cotransporter-specific substrate αMG stimulates endogenous glucagon secretion and ameliorates obesity-associated metabolic disorders in mice. Mol Metab, 105:102324. [PubMed]
- Ikeuchi Y, Kikuchi O, Kobayashi M, Tabei Y, Hashimoto H, Kobayashi R, Horii T, Hatada I, Miyatsuka T, Kitamura T. (2026/3/2) Pancreatic α-cell sodium-glucose cotransporter 1 (SGLT1) does not appear to contribute to hyperglucagonemia and glucose intolerance in diabetic mice. Endocr J, 73(3):471-482. [PubMed]
- Kawanabe-Kobayashi R, Uchiyama S, Yoshihara K, Koga K, Kojima D, McHugh TJ, Hatada I, Matsui K, Tanaka KF, Tsuda M. (2026/3/9) Descending locus coeruleus noradrenergic signaling to spinal astrocyte subset is required for stress-induced mechanical pain hypersensitivity. Elife, 14:RP104453. [PubMed]
- Fukunaka A, Isozaki A, Fujitani Y, Fukada T. (2026/3/20) Metal transporter ZIP13 at the crossroads of intracellular zinc and iron homeostasis. Biosci Biotechnol Biochem, 90(4):483-490. [PubMed]
- 佐々木 伸雄. (2025/4) オルガノイド培養法を用いた宿主-細菌の相互作用に関する研究. 決定版 オルガノイド実験スタンダード第2弾 (佐藤俊朗,武部貴則,永樂元次/編), 375-382.
- 北村 忠弘. (2025/8/1) グルカゴン/インクレチン革命. 診断と治療, 113(8): 905-909.
- 宮内 栄治、佐々木 伸雄. (2026/1/20) 食機能と腸管上皮栄養認識機構. 実験医学増刊 食で制御する腸内細菌叢と健康, 44(2): 63-68.