Munc13-4 regulates asthma and obesity in mice by controlling functions of CD11c+ antigen-presenting cells
Recently, common risk variants in the UNC13D gene were found by genome-wide association studies of asthma and obesity. Munc13-4, encoded by the UNC13D gene is known to regulate cytotoxic gra
How paternal mitochondria are recognized and removed from embryos via autophagy?
Mitochondria are important organelles that supply energy to cells and have their own mitochondrial DNA. Interestingly, mitochondrial DNA is inherited only from the mother (maternal inheritan
Elucidation of a part of molecular mechanisms of fast polyspermy block
In many sexually reproducing organisms, oocytes are fundamentally fertilized with one sperm. However, the mechanism of the polyspermy block, in which the oocyte only fertilizes with one of m
Cells in our body are subject to various stresses and damages, many of which are repaired. When the damage is severe, cells die by programmed cell death (apoptosis). However, how cells in di
Regulation of RNA methylation is essential for embryo implantation
Ryosuke Kobayashi PhD, Professor Izuho Hatada PhD from the Laboratory of Genome Science, Institute for Molecular and Cellular Regulation, Gunma University, and colleagues have elucidated the