Although metformin has antitumor effects, the detailed mechanism of action, particularly with respect to the cellular responses mediated through G protein-coupled receptors (GPCRs), remains

• 2025/03/14
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The matricellular protein Fibulin-5 (Fbln5) is a secreted protein that is essential for elastic fiber formation, and pancreatic islets are usually surrounded by the extracellular matrix (ECM

• 2025/01/24
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A research group led by Assistant Professor Yuto Yoshinari and Professor Takashi Nishimura (Laboratory of Metabolic Regulation and Genetics) and by Technical Staff Takayuki Yamada at the RIK

• 2025/01/10
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We have shown that cells expressing PP (PP cells) act as a new cell of origin for pancreatic cancer. In this study, we generated mice that activate an oncogene (SV40T) in cells expressing th

• 2024/06/11
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Recently, common risk variants in the UNC13D gene were found by genome-wide association studies of asthma and obesity. Munc13-4, encoded by the UNC13D gene is known to regulate cytotoxic gra

• 2024/03/18
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