Cells in our body are subject to various stresses and damages, many of which are repaired. When the damage is severe, cells die by programmed cell death (apoptosis). However, how cells in di
Regulation of RNA methylation is essential for embryo implantation
Ryosuke Kobayashi PhD, Professor Izuho Hatada PhD from the Laboratory of Genome Science, Institute for Molecular and Cellular Regulation, Gunma University, and colleagues have elucidated the
Protective effects of the early combination therapy on β-cells
Imeglimin and metformin act in metabolic organs, including β-cells, via different mechanisms. In the present study, we investigated the impacts of imeglimin, metformin, or their combination …
Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity
The laboratory of Professor Inagaki at the Institute for Biomedical Sciences, Gunma University, has elucidated the iron-mediated epigenomic mechanism during adipocyte differentiation. Iron
A disproportionality analysis of the adverse effect profiles of methimazole and propylthiouracil in patients with hyperthyroidism using the Japanese Adverse Drug Event Report Database
Antithyroid drugs (ATDs) are frequently used to achieve euthyroidism in patients with hyperthyroidism. ATDs cause characteristic common and rare adverse events; however, comprehensive compar