Divalent metal ions such as nickel, cobalt and manganese are known to induce hypoxia-inducible factors (HIFs) over several hours and are implicated in the inflammatory responses; however, th

• 2025/12/01
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Insulin-like growth factor -2 receptor (IGF2R), also known as cation-independent mannose-6-phosphate receptor (CI-MPR), is localized in cytosolic vesicles and is unique in its ability to tra

• 2025/10/06
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Akkermansia muciniphila is an obligate anaerobe that utilizes mucin in the gut and has been proposed as a next-generation probiotic due to its potential in mitigating metabolic disorders. Ho

• 2025/08/20
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Dysregulated α-cell function contributes to the development of diabetes. In this study, we found that treatment with imeglimin, an antidiabetic drug, prevents glucagon release and induces a …

• 2025/07/28
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Imeglimin is a drug for type 2 diabetes that promotes β-cell proliferation; however, the detailed underlying molecular mechanism remains unclear. We investigated metabolites in pancreatic is…

• 2025/07/14
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