Dysregulated α-cell function contributes to the development of diabetes. In this study, we found that treatment with imeglimin, an antidiabetic drug, prevents glucagon release and induces a …

• 2025/07/28
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Imeglimin is a drug for type 2 diabetes that promotes β-cell proliferation; however, the detailed underlying molecular mechanism remains unclear. We investigated metabolites in pancreatic is…

• 2025/07/14
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N6-methyladenosine (m6A) is an abundant chemical RNA modification involved in the regulation of many biological processes. The m6A demethylase FTO (fat mass and obesity-associated protein) i

• 2025/07/14
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Previous studies on probiotics have used cell lines, such as Caco-2, derived from colorectal cancer patient. In this study, the research group used organoid culture system that is close to t

• 2025/07/07
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Purine nucleotides and their derivatives play crucial roles in many cellular processes, making them essential metabolites for all living organisms. Purine nucleotides are synthesized through

• 2025/05/01
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