History
| 1951 March | The Endocrine Research Facility of medicine was founded in Gunma University School. |
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| 1951 April | First Department (Organ Functions) was started. Research Building 1was constructed. |
| 1952 April | Second Department (Functional Morphology) was started. |
| 1953 April | Third Department (Experimental Biology) was started. |
| 1954 May | Research Building 2 was constructed. |
| 1955 July | Second Department was shifted to Department of Biological Functions. Forth Department (Morphology) was started. |
| 1957 April | Fifth Department (Physical Biochemistry) was started. |
| 1963 March | The Facility was graded up to the Institute of Endocrinology in the Gunma University. |
| 1963 April | The Institute consisted of First Research Dept.(Morphology), Second Research Dept.(Physiology), Third Research Dept.(Comparative Endocrinology), Fourth Research Dept.(Physical Biochemistry), and Fifth Research Dept.(Pharmaceutical Chemistry). |
| 1966 April | Sixth Research Department (Protein Chemistry) was started. |
| 1967 March | Headquerter Building was constructed. |
| 1972 May | Research Facility (Hormone Assay Center) was started. |
| 1994 June | The Institute was renovated to the Institute for Molecular and Cellular Regulation, and Hormone Assay Center to the Biosignal Research Center. |
| 2002 October | Accepted as a Center for the 21st COE Program. |
| 2004 January | Construction of new building and renovation of old building were completed. |
| 2004 December | Biosignal Research Center is changed to Biosignal Genome Resource Center. |
| 2007 April | The Institute for Molecular and Cellular Regulation was reorganized and a new research center, namely the Research Center for Metabolic Signals was built. |
| 2007 June | Accepted as a center for the Global COE Program. |
| 2009 June | Accepted as a Collaborative Research Center for endocrinology and metabolism. |
| 2014 October | Associated with Gunma University Initiative for Advanced Research (Research Program for Signal Transduction). |
| 2016 April | Colaborative Research Center for Endcrinology and Metabolism was renewed |
| 2019 March | The Research Center for Biosignal was abolished |
| 2019 April | IMCR Joint Usage/Research Support Center was built |
| 2022 April | Collaborative Research Center for Endocrinology and Metabolism was renewed |
| 2024 April | Three departments was built Department of Biological Sciences Department of Genomics and Epigenetics Department of Endocrine and Metabolic Diseases Metabolic Signal Research Center was merged with Lifestyle Disease Research Center |













