Morita S, Horii T, Kimura M, Hatada I (IMCR, Gunma Univ.) Arai Y (National Cerebral and Cardiovascular Center) Kamei Y (Kyoto Prefectural Univ.) Ogawa Y (Tokyo Medical and Dental Univ.)

About

C57BL/6J (B6) mice are susceptible to high-fat diet (HFD)-induced obesity and PWK mice are resistant. Our study reports evidence for a paternal transmission of HFD-induced obesity and a correlated expression of Igf2 and Peg3 imprinted genes. We generated and analyzed reciprocal crosses between these mice and found paternal transmission of diet-induced obesity. Expression analysis indicates that Igf2 and Peg3, which are paternally expressed imprinted genes involved in the regulation of body fat accumulation, were down-regulated in F1 mice from B6 father, which are susceptible to HFD-induced obesity, but not in F1 mice from PWK father, which are resistant. Furthermore, in vitro analysis showed that Igf2, but not Peg3, had an anti-inflammatory effect on TNF-α induced MCP-1 expression in adipocytes. Taken together, our findings suggest that the down-regulation of Igf2 and Peg3 imprinted genes in adipocytes may be involved in the paternal transmission of HFD-induced obesity.

Paper information

Paternal Allele Influences High Fat Diet-Induced Obesity.
Morita S, Horii T, Kimura M, Arai Y, Kamei Y, Ogawa Y, Hatada I.
PLoS One 9: e85477, 2014

Online URL

http://www.ncbi.nlm.nih.gov/pubmed/24416415

Lab HP

http://epigenome.dept.showa.gunma-u.ac.jp/~hatada/index.php?id=44