Ikuko Maejima1 , Taichi Hara2, Satoshi Tsukamoto3, Hiroyuki Koizumi4,5, Takeshi Kawauchi6, Tomoko Akuzawa1 , Rika Hirai1 , Hisae Kobayashi1 , Inoya Isobe1 , Kazuo Emoto4, Hidetaka Kosako7 & Ken Sato1,8 1 Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371-8512, Japan. 2 Laboratory of Food and Life Science, Faculty of Human Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan. 3 Laboratory Animal and Genome Sciences Section, National Institutes for Quantum and Radiological Science and Technology, Chiba, Chiba 263-8555, Japan. 4Department of Biological Sciences, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. 5Department of Molecular and Cellular Biology, School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima 963-8611, Japan. 6Department of Adaptive and Maladaptive Responses in Health and Diseases, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. 7Division of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima, Tokushima 770-8503, Japan. 8Gunma University Initiative for Advanced Research (GIAR), Gunma University, Maebashi, Gunma 371-8512, Japan.
About
Professor Ken Sato and Assistant Professor Ikuko Maejima in the Laboratory of Molecular Traffic, in collaboration with Waseda University, National Institutes for Quantum and Radiological Science and Technology, the University of Tokyo, Kyoto University, Ohu University, and Tokushima University, has revealed that RAB35 is required for hippocampal development and functions by regulating neuronal cell distribution. RAB35 is known to be a multifunctional small GTPase that regulates endocytic recycling, cytoskeletal rearrangement, and cytokinesis. We found that brain-specific Rab35-knockout mice exhibit severe defects in hippocampal lamination due to impaired distribution of pyramidal neurons. We also revealed that Rab35-knockout mice show defects in spatial memory and anxiety-related behaviors. Collectively, our findings revealed that RAB35 is required for precise neuronal distribution in the developing hippocampus by regulating the expression of cell adhesion molecules, thereby influencing spatial memory. Our study are expected to contribute to the elucidation of the pathophysiology of neurodegenerative diseases by elucidating one aspect of the regulation of higher brain functions regulated by the intracellular membrane trafficking system.
Paper information
Maejima I, Hara T, Tsukamoto S, Koizumi H, Kawauchi T, Akuzawa T, Hirai R, Kobayashi H, Isobe I, Emoto K, Kosako H, Sato K. RAB35 is required for murine hippocampal development and functions by regulating neuronal cell distribution. Commun Biol. 2023 Apr 21;6(1):440.
Online URL
https://www.nature.com/articles/s42003-023-04826-x
