Johan Medina (First author, Institute for Molecular and Cellular Regulation, Gunma University),Yuko Nakagawa (Institute for Molecular and Cellular Regulation, Gunma University),Masahiro Nagasawa (Institute for Molecular and Cellular Regulation, Gunma University),Anny Fernandez (Institute for Molecular and Cellular Regulation, Gunma University), Kazushige Sakaguchi (Institute of Advanced Medicine, Wakayama Medical University),Tetsuya Kitaguchi (Waseda Bioscience Research Institute in Singapore, Organization for University Research Initiatives, Waseda University),Itaru Kojima (Corresponding author, Institute for Molecular and Cellular Regulation, Gunma University)
About
Calcium-sensing receptor (CaSR) belongs to the class C G protein-coupled receptor and is activated by an elevation of the extracellular calcium concentration. We show here that physiological concentrations of glucose allosterically stimulate CaSR and elevate intracellular Ca2+ concentration. Sucralose and artificial sweeteners also stimulate CaSR but they are less potent than glucose. 
Paper information
Positive Allosteric Modulation of the Calcium-sensing Receptor by Physiological Concentrations of Glucose
Medina J, Nakagawa Y, Nagasawa M, Fernandez A, Sakaguchi K, Kitaguchi T, Kojima I.
Journal of Biological Chemistry Sep 9, 2016
DOI: 10.1074/jbc.M116.729863
Online URL
http://www.jbc.org/cgi/doi/10.1074/jbc.M116.729863
