Yuki Akieda(1,2), Shohei Ogamino(1), Hironobu Furuie(3,4), Shizuka Ishitani(1), Ryutaro Akiyoshi(5), Jumpei Nogami(6), Takamasa Masuda(3), Nobuyuki Shimizu(3), Yasuyuki Ohkawa(6) & Tohru Ishitani(1,2,3) (1) Laboratory of Integrated Signaling Systems, Department of Molecular Medicine, Institute for Molecular & Cellular Regulation, Gunma University (2) Department of Homeostatic Regulation, Division of Cellular and Molecular Biology, Research Institute for Microbial Diseases, Osaka University (3) Medical Institute of Bioregulation, Kyushu University (4) Graduate School of Medical Sciences, Kyushu University (5) Biological Evaluation Technology 2, Research and Development, Olympus Corp. (6) Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University
A research group including Dr. Yuki Akieda, Ph.D. student Shohei Ogamino and Prof. Tohru Ishitani with collaborators Prof. Yasuyuki Ohkawa of Medical Institute of Bioregulation at Kyushu University, and researchers at Olympus Corp. uncovered that ‘morphogen-gradient noise-cancelling system’ senses and eliminates unhealthy cells, which are accidentally generated during embryogenesis. This system is essential for the construction of appropriate tissue morphogenesis and may support tissue homeostasis and disease prevention. In future, this study can help to explain the mechanisms involved in the formation of cancer and the occurrence of congenital diseases. In addition, these findings may be useful for designing new diagnostic and therapeutic methods for these diseases.
Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo, Yuki Akieda, Shohei Ogamino, Hironobu Furuie, Shizuka Ishitani, Ryutaro Akiyoshi, Jumpei Nogami, Takamasa Masuda, Nobuyuki Shimizu, Yasuyuki Ohkawa & Tohru Ishitani, Nature Communications, 2019, 10(1):4710. doi: 10.1038/s41467-019-12609-4