Saegusa K (1), Sato M, Morooka N (1), Hara T (1), Sato K (1). (1) Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan. (2 ) Laboratory of Molecular Membrane Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
About
Lipoproteins such as low-density lipoproteins (LDLs) and chyromicrons (CMs) regulate the overall lipid homeostasis in animals. However, the molecular mechanisms underlying lipoprotein trafficking remain poorly understood. In this study, we found that SFT-4/Surf4 family proteins are required for the efficient export of soluble proteins including lipoproteins from the endoplasmic reticulum in C. elegans and human hepatic cultured cells. our findings not only provide insights into the mechanisms underlying the biogenesis and secretion of very-low-density lipoproteins (VLDLs) and CMs, but also indicate that C. elegans could serve as a highly favorable model system for identifying new targets for the treatment of dyslipidemia, including CM retention diseases and hyperlipidemia.
Paper information
SFT-4/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization.J Cell Biol. 2018 Apr 11. pii: jcb.201708115. doi: 10.1083/jcb.201708115. [Epub ahead of print]PMID:29643117
Online URL
http://jcb.rupress.org/content/early/2018/04/10/jcb.201708115.long
