Gomi H, Morikawa S, Shinmura N, Moki H, Yasui T, Tsukise A (College of Bioresource Sciences, Nihon Univ.) Torii S (IMCR, Gunma Univ.) Watanabe T (Asahikawa Medical College) Maeda Y, Hosaka M (Akita Prefectural Univ.)
About
The expression of secretogranin III (SgIII) in chicken endocrine cells has not been investigated. We used immunoblotting to reveal the similarities between the expression patterns of SgIII in the common endocrine glands of chickens and rats. Using immunohistochemistry, we also examined the expression of SgIII in a wide range of chicken endocrine glands and gastrointestinal endocrine cells (GECs). SgIII was expressed in the pituitary, pineal, adrenal (medullary parts), parathyroid, and ultimobranchial glands, but not in the thyroid gland. It was also expressed in GECs of the stomach (proventriculus and gizzard), small and large intestines, and pancreatic islet cells. These SgIII-expressing cells co-expressed serotonin, somatostatin, gastric inhibitory polypeptide, glucagon-like peptide-1, glucagon, or insulin. These results suggest that SgIII is expressed in the endocrine cells that secrete peptide hormones, which mature via the intragranular enzymatic processing of prohormones and physiologically active amines in chickens.
Paper information
Expression of Secretogranin III in Chicken Endocrine Cells: Its Relevance to the Secretory Granule Properties of Peptide Prohormone Processing and Bioactive Amine Content.
Gomi H, Morikawa S, Shinmura N, Moki H, Yasui T, Tsukise A, Torii S, Watanabe T, Maeda Y, Hosaka M.
J Histochem Cytochem, 63: 350-66, 2015
Online URL
http://www.ncbi.nlm.nih.gov/pubmed/25673289
