Keiko Saegusa1, Kohichi Matsunaga2, Miharu Maeda3, Kota Saito3, Tetsuro Izumi2, and Ken Sato1,* 1Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371-8512, Japan 2Laboratory of Molecular Endocrinology and Metabolism, Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371-8512, Japan 3Department of Biological Informatics and Experimental Therapeutics, Graduate School of Medicine, Akita University, Akita, 010-8543, Japan
About
In this study, we identified Surf4 as a novel factor involved in insulin secretion from pancreatic cells. We showed that Surf4 localizes to the ER (endoplasmic reticulum) and promotes the export of the precursor proteins (proinsulin) from the ER to the Golgi apparatus by sorting them to COPII-coated vesicles. As Surf4 promotes the export of proinsulin from the endoplasmic reticulum, it may be a new and different type of target for drug discovery that increases insulin secretion.
Paper information
Commun Biol. 2022 May 13;5(1):458. doi: 10.1038/s42003-022-03417-6.PMID: 35562580
Online URL
https://www.nature.com/articles/s42003-022-03417-6
