1. Honzawa N, Fujimoto K, Kobayashi M, Kohno D, Kikuchi O, Yokota-Hashimoto H, Wada E, Ikeuchi Y, Tabei Y, Dorn GW 2nd, Utsunomiya K, Nishimura R, Kitamura T. (2022/4/4) Protein Kinase C (Pkc)-δ Mediates Arginine-Induced Glucagon Secretion in Pancreatic α-Cells. Int J Mol Sci, 23(7):4003. [PubMed]
2. Katsumura S, Siddiqui N, Goldsmith MR, Cheah JH, Fujikawa T, Minegishi G, Yamagata A, Yabuki Y, Kobayashi K, Shirouzu M, Inagaki T, Huang TH, Musi N, Topisirovic I, Larsson O, Morita M. (2022/4/5) Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure. Cell Metab, 34(4):564-580. [PubMed]
3. Takaine M, Imamura H, Yoshida S. (2022/4/19)High and stable ATP levels prevent aberrant intracellular protein aggregation. Elife, 19:11:e67659. [PubMed]
4. Ciesielski HM, Nishida H, Takano T, Fukuhara A, Otani T, Ikegawa Y, Okada O, Nishimura T, Furuse M, Yoo SK. (2022/ 4/25) Erebosis is a new a cell death mechanism to maintains homeostasis in gut enterocytes. PLoS Biol, 20(4): 1-21. [PubMed]
5. Watanabe A, Okamoto N. (2022/5/1) Interorgan communication through peripherally derived peptide hormones in Drosophila. Fly (Austin), (1):152-176. [PubMed]
6. Miyauchi E, Shimokawa C, Steimle A, Desai MS, Ohno H. (2022/5/9) The impact of the gut microbiome on extra-intestinal autoimmune diseases. Nat Rev Immunol, 23:4370. [PubMed]
7. Yoshimatsu Y, Sujino T, Miyamoto K, Harada Y, Tanemoto S, Ono K, Umeda S, Yoshida K, Teratani T, Suzuki T, Mikami Y, Nakamoto N, Sasaki N, Takabayashi K, Hosoe N, Ogata H, Sawada K, Imamura T, Yoshimura A, Kanai T.(2022/5/10) Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut. Cell Rep, 39(6):110773. [PubMed]
8. Sato K. (2022/5/11) Multiple roles of endocytosis and autophagy in intracellular remodeling during oocyte-to-embryo transition. Proc Jpn Acad Ser B Phys Biol Sci, 98(5):207-221. [PubMed]
9. Saegusa K, Matsunaga K, Maeda M, Saito K, Izumi T, Sato K. (2022/5/13) Cargo receptor Surf4 regulates endoplasmic reticulum export of proinsulin in pancreatic β-cells. Commun Biol, 5(1):458. [PubMed]
10. Mizuno K. Izumi T. (2022/5/21) Munc13b stimulus-dependently accumulates on granuphilin-mediated, docked granules prior to fusion. Cell Struct Funct, 47(1):31-41. [PubMed]
11. Sano H, Nakamura A, Yamane M, Niwa H, Nishimura T, Araki K, Takemoto K, Ishiguro KI, Aoki H, Kato Y, Kojima M. (2022/6/10) The polyol pathway is an evolutionarily conserved system for sensing glucose uptake. PLoS Biol, 20(6):e3001678. [PubMed]
12. Inoue R, Tsuno T, Togashi Y, Okuyama T, Sato A, Nishiyama K, Kyohara M, Li J, Fukushima S, Kin T, Miyashita D, Shiba Y, Atobe Y, Kiyonari H, Bando K, Shapiro AMJ, Funakoshi K, Kulkarni RN, Terauchi Y, Shirakawa J. (2022/6/14) Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER. iScience, 25(7):104603. [PubMed]
13. Norizuki T, Minamino N, Sato M, Tsukaya H, Ueda T. (2022/6/14) Dynamic rearrangement and autophagic degradation of mitochondria during spermiogenesis in the liverwort Marchantia polymorpha. Cell Rep, 39(11):110975. [PubMed]
14. Suzuki L, Miyatsuka T, Himuro M, Wakabayashi Y, Osonoi S, Miura M, Katahira T, Fujitani Y, Iida H, Mizukami H, Nishida Y, Watada H. (2022/6/30) Cumulative autophagy insufficiency in mice leads to progression of β-cell failure. Biochem Biophys Res Commun, 611:38-45. [PubMed]
15. Sobajima M, Miyake M, Hamada Y, Tsugawa K, Oyadomari M, Inoue R, Shirakawa J, Arima H, Oyadomari S. (2022/6/30) The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion. Biochem Biophys Res Commun, 611:165-171. [PubMed]
16. Morita A. Satouh Y. Sato K. Iwase A. (2022/7/14) Significance of the association between early embryonic development and endocytosis. Med Mol Morphol, 55(3):167-173. [PubMed]
17. Togashi Y, Miyashita D, Tsuno T, Inoue R, Okuyama T, Kyohara M, Nishiyama K, Arai M, Kanematsu K, Kanataki S, Terauchi Y, Shirakawa J. (2022/7/23) Abdominal aortic calcification is associated with Fibrosis-4 index and low body mass index in type 2 diabetes: a retrospective cross-sectional study. J Diabetes Investig
    . 13(11):1861-1872. [PubMed]
18. Kosakamoto H, Okamoto N, Aikawa H, Sugiura Y, Suematsu M, Niwa R, Miura M, Obata F. (2022/7/25) Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila. Nat Metab, 4(7):944-959. [PubMed]
19. Takehumi Tozawa, Kohichi Matsunaga, Tetsuro Izumi,Naotake Shigehisa, Takamasa Uekita, Masato Taoka, and Tohru Ichimura. (2022/8/5) Ubiquitination-coupled liquid phase separation regulates the accumulation of the TRIM family of ubiquitin ligases into cytoplasmic bodies. PLoS One, 17(8):e0272700. [PubMed]
20. Yamazaki K, Miyauchi E, Kato T, Sato K, Suda W, Tsuzuno T, Yamada-Hara M, Sasaki N, Ohno H, Yamazaki K. (2022/8/11) Dysbiotic human oral microbiota alters systemic metabolism via modulation of gut microbiota in germ-free mice. J Oral Microbiol, 14(1):2110194. [PubMed]
21. Saito D, Nakagawa Y, Sato T, Fukunaka A, Pereye OB, Maruyama N, Watada H, Fujitani Y. (2022/8/17) Establishment of an enzyme-linked immunosorbent assay for mouse pancreatic polypeptide clarifies the regulatory mechanism of its secretion from pancreatic γ cells. PLoS One, 17(8):e0269958. [PubMed]
22. Takahashi H, Yang G, Yoneshiro T, Abe Y, Ito R, Yang C, Nakazono J, Okamoto-Katsuyama M, Uchida A, Arai M, Jin H, Choi H, Tumenjargal M, Xie S, Zhang J, Sagae H, Zhao Y, Yamaguchi R, Nomura Y, Shimizu Y, Yamada K, Yasuda S, Kimura H, Tanaka T, Wada Y, Kodama T, Aburatani H, Zhu MS, Inagaki T, Osborne TF, Kawamura T, Ishihama Y, Matsumura Y, Sakai J. (2022/9/29) MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis. Nat Commun, 13(1):5715. [PubMed]
23. Horii T, Morita S, Hatada I. (2022/9/30) Generation of Epigenetic Disease Model Mice by Targeted Demethylation of the Epigenome. Methods Mol Biol, 2577:255-268. [PubMed]
24. Morita S, Horii T, Hatada I. (2022/9/30) Regulation of Gene Expression Using dCas9-SunTag Platforms. Methods Mol Biol, 2577:189-195. [PubMed]
25. Shirakawa J, Togashi Y, Basile G, Okuyama T, Inoue R, Fernandez M, Kyohara M, De Jesus DF, Goto N, Zhang W, Tsuno T, Kin T, Pan H, Dreyfuss JM, Shapiro AMJ, Yi P, Terauchi Y,Kulkarni RN. (2022/10/4) E2F1 transcription factor mediates a link between fat and islets to promote β-cell proliferation in response to acute insulin resistance. Cell Rep, 41(1):111436. [PubMed]
26. Hayakawa Y, Takaine M, Ngo KX, Imai T, Yamada, MD, Behjat AB, Umeda K, Hirose K, Yurtsever A, Kodera N, Tokuraku K, Numata O, Fukuma T, Ando T, Nakano K, Uyeda TQ. (2022/10/26) Actin-binding domain of Rng2 sparsely bound on F-actin strongly inhibits actin movement on myosin II. Life Sci Alliance, 6(1):e202201469. [PubMed]
27. Yoshinaga M, Han K, Morgens DW, Horii T, Kobayashi R, Tsuruyama T, Hia F, Yasukura S, Kajiya A, Cai T, Cruz PHC, Vandenbon A, Suzuki Y, Kawahara Y, Hatada I, Bassik MC, Takeuchi O. (2022/10/28) The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity. Nat Commun, 13(1):6435. [PubMed]
28. Kyohara M, Miyashita D, Inoue R, Nishiyama K, Tsuno T, Okuyama T, Togashi Y, Terauchi Y, Shirakawa J. (2022/11/4) Association between circulating SerpinB1 levels and insulin sensitivity in Japanese with type 2 diabetes: A single-center, cross-sectional, observational study. PLoS One, 17(11):e0276915. [PubMed]
29. Kobayashi R, Kawabata-Iwakawa R, Sugiyama M, Oyama T, Ohtsuka M, Horii T, Morita S, Nishiyama M, Hatada I. (2022/11/15) Multiplexed genome editing by in vivo electroporation of Cas9 ribonucleoproteins effectively induces endometrial carcinoma in mice. Int J Cancer, 152(11):2331-2337. [PubMed]
30. Miyashita D, Inoue R, Tsuno T, Okuyama T, Kyohara M, Nakahashi-Oda C, Nishiyama K, Fukushima S, Inada Y, Togashi Y, Shibuya A, Terauchi Y, Shirakawa J. (2022/11/23) Protective effects of S100A8 on sepsis mortality: links to sepsis risk in obesity and diabetes. iScience, 25(12):105662. [PubMed]
31. Banzai K, Nishimura T. (2022/12/9) Isolation of a novel missense mutation in insulin receptor as a spontaneous revertant of ImpL2 mutation in Drosophila. Development, 150(1):dev201248. [PubMed]
32. Wakabayashi Y, Miyatsuka T, Miura M, Himuro M, Taguchi T, Iida H, Nishida Y, Fujitani Y, Watada H. (2022/12/10) STAT3 suppression and β-cell ablation enhance α-to-β reprogramming mediated by Pdx1. Sci Rep, 12(1):21419. [PubMed]
33. Horii T, Morita S, Kimura M, Hatada I. (2022/12/16) Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system. Epigenetics Chromatin, 15(1):40. [PubMed]
34. Wong A, Pritchard S, Moore M, Akhaphong B, Avula N, Beetch M, Fujitani Y, Alejandro EU. (2023/1/6) Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion. J Biol Chem, 299(2):102878. [PubMed]
35. Oda T, Gotoh N, Kasamatsu T, Handa H, Saitoh T, Sasaki N. (2023/1/15) DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nulear foci and phase separation. Cell Prolif, 56(6):e13398. [PubMed]
36. Kanaoka Y, Onodera K, Watanabe K, Hayashi Y, Usui T, Uemura T, Hattori Y. (2023/1/17) Inter-organ Wingless/Ror/Akt signaling regulates nutrient-dependent hyperarborization of somatosensory neurons . Elife, 12:e79461. [PubMed]
37. Takeuchi T, Kameyama K, Miyauchi E, Nakanishi Y, Kanaya T, Fujii T, Kato T, Sasaki T, Tachibana N, Negishi H, Matsui M, Ohno H. (2023/1/17) Fatty acid overproduction by gut commensal microbiota exacerbates obesity. Cell Metab, 35(2):361-375.e9. [PubMed]
38. Ishihara R, Oda T, Murakami Y, Matsumura I, Watanabe S, Asao Y, Masuda Y, Gotoh N, Kasamatsu T, Takei H, Kobayashi N, Sasaki N, Saitoh T, Murakami H, Handa H. (2023/1/22) Myeloma Microenvironmental TIMP1 Induces the Invasive Phenotype in Fibroblasts to Modulate Disease Progression. Int J Mol Sci, 24(3):2216. [PubMed]
39. Kasano-Camones CI, Takizawa M, Ohshima N, Saito C, Iwasaki W, Nakagawa Y, Fujitani Y, Yoshida R, Saito Y, Izumi T, Terawaki SI, Sakaguchi M, Gonzalez FJ, Inoue Y. (2023/1/23) PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice. J Biochem, 173(5):393-411. [PubMed]
40. Satouh, Y. Sato, K. (2023/1/28) Reorganization, specialization, and degradation of oocyte maternal components for early development. Reprod Med Biol, 22(1):e12505. [PubMed]
41. Ikegawa Y, Combet C, Groussin M, Navratil V, Safar-Remali S, Shiota T, Aouacheria A, Yoo SK. (2023/2/2) Evidence for existence of an apoptosis-inducing BH3-only protein, sayonara, in Drosophila. EMBO J, 42(8):e110454. [PubMed]
42. Norizuki T, Minamino N, Sato M, Ueda T. (2023/2/9) Autophagy regulates plastid reorganization during spermatogenesis in the liverwort Marchantia polymorpha. Front Plant Sci, 14:1101983. [PubMed]
43. Kobayashi R, Horii T, Hatada I. (2023/2/12) Efficient Detection of Flox Mice Using In Vitro Cre Recombination. Methods Mol Biol, 2637:149-159. [PubMed]
44. Horii T, Kobayashi R, Hatada I. (2023/2/12) Generation of Floxed Mice by Sequential Electroporation. Methods Mol Biol, 2637:135-147. [PubMed]
45. Horii T, Hatada I. (2023/2/12) Generation of Genome-Edited Mice by Cytoplasmic Injection of CRISPR-Cas9 RNA. Methods Mol Biol, 2637:75-86. [PubMed]
46. Hatada I., Morita S, Horii T. (2023/2/12) CRISPR/Cas9. Methods Mol Biol, 2637:41-47. [PubMed]
47. Hoshino R, Sano H, Yoshinari Y, Nishimura T, Niwa R. (2023/2/14) Circulating fructose regulates a germline stem cell increase via gustatory receptor-mediated gut hormone secretion in mated Drosophila. Sci Adv, 9(8):eadd5551. [PubMed]
48. Wang H, Yuan YC, Chang C, Izumi T, Wang HH, and Yang JK. (2023/2/21) The signaling protein GIV/Girdin mediates the Nephrin-dependent insulin secretion of pancreatic islet β cells in response to high glucose. J Biol Chem, 299(4):103045. [PubMed]
49. Zhao M, Okunishi K, Bu Y, Kikuchi O, Wang H, Kitamura T, Izumi T. (2023/2/22) Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders. JCI Insight, 8(4):e161229. [PubMed]
50. Shirakawa J. (2023/3/5) Signaling pathways that regulate adaptive β-cell proliferation for the treatment of diabetes. J Diabetes Investig, (2023/3/5) 14(6):735-740. [PubMed]
51. Zhao K, Kohichi Matsunaga K, Mizuno K, Wang H, Okunishi K and Izumi T. (2023/3/6) Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis. Elife, 21:12:e82821. [PubMed]
52. Fukunaka A, Shimura M, Ichinose T, Pereye OB, Nakagawa Y, Tamura Y, Mizutani W, Inoue R, Inoue T, Tanaka Y, Sato T, Saito T, Fukada T, Nishida Y, Miyatsuka T, Shirakawa J, Watada H, Matsuyama T, Fujitani Y. (2023/3/15) Zinc and iron dynamics in human islet amyloid polypeptide‑induced diabetes mouse model. Sci Rep, 13(1):3484. [PubMed]
53. Aoyama S, Nishida Y, Uzawa H, Himuro M, Kanai A, Ueki K, Minami Ito, Iida H, Tanida I, Miyatsuka T, Fujitani Y, Matsumoto M, Watada H. (2023/3/20) Monitoring autophagic flux in vivo revealed its physiological response and significance of heterogeneity in pancreatic beta cells. Cell Chem Biol, 30(6):658-671.e4. [PubMed]
54. Kobayashi M, Maruyama N, Yamamoto Y, Togawa T, Ida T, Yoshida M, Miyazato M, Kitada M, Hayashi Y, Kashiwagi A, Kitamura T. (2023/3/ ) A newly developed glucagon sandwich ELISA is useful for more accurate glucagon evaluation than the currently used sandwich ELISA in subjects with elevated plasma proglucagon-derived peptide levels. J Diabetes Investig,14(5):648-658.  [PubMed]
55. Okada A, Yamashita MY, Tominaga Y, Jo K, Mori H, Suzuki R, Ishizu M , Tamaki M, Akehi Y, Takashi Y, Koga D, Shimokita E, Tanihara F, Kurahashi K, Yoshida S, Mitsui Y, Masuda S, Endo I, Aihara KI, Kagami S, Abe M, Ferreri K, Fujitani Y, Matsuhisa M, Kuroda A. (2023/3 /6) Novel method utilizing bisulfite conversion with dual amplification-refractory mutation system polymerase chain reaction to detect circulating pancreatic β-cell cfDNA. J Diabetes Investig, 13(7):1140-1148. [PubMed]