We investigated the physiological roles of Munc13-4, one of Rab27 effectors, in mouse models of asthma and metabolic disorders. Systemic Munc13-4 deficiency exacerbated both allergic lung inflammation and high fat diet-induced obesity/diabetes. Mechanistically, Munc13-4 deficiency impaired secretion of immunoregulatory cytokines IL-10 and IL-12 by CD11c+ antigen presenting cells, which resulted in enhanced allergic lung inflammation and chronic inflammation in adipose tissues under high fat diet condition, the latter of which further exacerbated the production of GDF3, one of the obesity-promoting cytokines, and fat accumulation, in the white adipose tissues.
https://doi.org/10.1111/all.16087

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