Ryosuke Kobayashi PhD, Professor Izuho Hatada PhD (laboratory of Genome Science, Institute for Molecular and Cellular Regulation, Gunma University) and colleagues have elucidated that the regulation of RNA methylation in the uterus is essential for successful embryo implantation in mice.
Recently, N6-methyladenosine (m6A), one of the chemical modifications of RNA molecules, has attracted attention as an epigenetic mechanism that regulates various life phenomena and disease pathologies. In this study, we generated genetically engineered mice with a uterus-specific deletion of the Mettl14 gene, which is important for RNA m6A modification, and showed that Mettl14-deficient female mice become infertile due to implantation failure caused by abnormal activation of estrogen-responsive signaling in the uterus.
The results of this study are expected to lead to research for the development of diagnostic and therapeutic methods for early pregnancy miscarriages, including recurrent miscarriages.

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