The research team, led by Professor Inagaki, from the Institute for Molecular and Cellular Regulation at Gunma University, has investigated the epigenetic mechanisms regulated by iron during adipocyte differentiation. Iron is indispensable for various biological functions; however, its levels are tightly controlled within cells due to its involvement with the generation of harmful reactive oxygen species. Here, we have identified that the iron stored in ferritin is provided and subsequently transported into the nucleus through PCBPs during adipocyte differentiation. Epigenetic mechanisms play a vital role in accurately interpreting and decoding the genetic information stored in the nucleus. We have further identified detailed mechanisms how iron regulates the activity of epigenomic enzymes to govern adipocyte differentiation.

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