Research

Epigenetic regulation of gene expression is independent of genomic sequence and therefore can flexibly respond to environmental factors. We are currently investigating various epigenetic mechanisms by which the environmental factors are linked to metabolic diseases. Main focus of our research is histone modification which regulates gene expression through changing chromatin structure and cofactor recruitment. Using techniques of transcriptomics, epigenetics, proteomics and animal models, we intend to elucidate the detail mechanisms of epigenetic regulations of energy metabolism and adipose cell development.

On-going projects

1. Investigation of transcriptional regulation mechanisms regulated by histone demethylases
2. Elucidation of epigenetics in adipocyte differentiation and trans-differentiation
3. Comprehensive analysis of histone codes
4. Nuclear receptors and endocrine fibroblast growth factors

Keywords

Epigenome, metabolic diseases, energy metabolism, transcription, chromatin structure

Select References

1. Abe Y. et al. (2018). Nature Communications 19;9(1):1556
2. Inagaki T. et al. (2016). Nature Reviews Molecular Cell Biology 17(8):480-95
3. Abe Y. et al. (2015). Nature Communications 7;6:7052
4. Inagaki T. et al. (2009). Genes to Cells 14(8):991-1001
5. Inagaki T. et al. (2007). Cell Metabolism 5(6), 415-425
6. Inagaki T. et al. (2005). Cell Metabolism 2(4), 217-225