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群馬大学 生体調節研究所

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Molecular Traffic

佐藤健写真

Professor: SATO Ken
sato-ken*gunma-u.ac.jp
(*=@)
Lab Homepage
http://traffic.dept.med.gunma-u.ac.jp/

 

Member

Professor: SATO Ken
Associate Professor: SATOUH Yuhkoh
Assistant Professor: MAJIMA Ikuko
Postdoctoral Fellow: KAWASAKI Ichiro
Postdoctoral Fellow: HIRAI Rika
JSPS Research Fellow: SUGIURA Kenta
Technical Assistant: AKUZAWA Tomoko
Technical Assistant: SETO Mayumi
Graduate Student: SUTO Shunichi
Graduate Student: MICHIZAKI Mamoru

Professor: SATO Ken Associate Professor: SATOUH Yuhkoh Assistant Professor: MAJIMA IkukoProfessor: SATO Ken Associate Professor: SATOUH Yuhkoh Assistant Professor: MAJIMA IkukoProfessor: SATO Ken Associate Professor: SATOUH Yuhkoh Assistant Professor: MAJIMA Ikuko●283283

Research

Membrane trafficking plays essential roles not only in secretion and nutrient uptake but also in various physiological processes such as those involving the endocrine system, metabolic system, and nervous system in animals. In our laboratory, we study the molecular mechanisms and physiological functions of membrane trafficking in multicellular organisms by using the nematode Caenorhabditis elegans and mice as model systems. In addition, we study the molecular mechanisms underlying protein-misfolding diseases, in which abnormal membrane proteins accumulate in the endoplasmic reticulum (ER), in order to discover new targets for the treatment of such diseases.

moltra en

 

On-going projects

  1. Analysis of molecular mechanisms underlying low-density lipoprotein trafficking in C. elegans
  2. Analysis of physiological functions of membrane trafficking during development
  3. Analysis of the molecular mechanisms underlying ER retention of disease-associated membrane proteins

Keywords

Membrane trafficking, Secretion, Metabolism, Development, C. elegans, Mouse, Fertilization, Autophagy, Mitochondria, Endoplasmic reticulum

Select References

  1. Morita A. et al. (2021) Development. 148(14):dev199461
  2. Kunii M. et al. (2021) J Cell Biol. 220(1):e201910080
  3. Yamamoto YH. et al. (2020) J Cell Biol. 219(8):e201903127
  4. Umeda R. et al. (2020) Nat Commun. 11(1):1606
  5. Saegusa K. et al. (2018) J. Cell Biol. 217(6):2073-2085
  6. Sato M. et al. (2018) Nature Cell Bilol. 20(1):81-91
  7. Sakaguchi A. et al. (2015) Dev. Cell. 35(2):211-21
  8. Hara T. et al. (2014) Sci Rep. 4:6992
  9. Saegusa K. et al. (2014) Mol Biol Cell. 25(20):3095-104
  10. Sato M. et al. (2014) Development. 141(6):1324-31
  11. Sato M. and Sato K. (2011) Science. 334(6059):1141-4

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