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群馬大学 生体調節研究所

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Cell Signaling

Assistant Professor: TAKAINE Masakatsu
masaktakaine*gunma-u.ac.jp
(*=@)
Lab website
https://www.giar.gunma-u.ac.jp/program/program_takaine/

 

Member

Assistant Professor : Masakatsu Takaine

Assistant Professor : Masakatsu TakaineAssistant Professor : Masakatsu TakaineAssistant Professor : Masakatsu Takaine●271271

Research

Cells are constantly exposed to various stimuli such as environmental stress and nutrient sources, and if they cannot respond appropriately to such external stimuli, they will be damaged, leading to aging or cell death. Therefore, a detailed understanding of the cell response mechanism is necessary for the development of treatments for lifestyle-related diseases and aging.
Using the budding yeast Saccharomyces cerevisiae, which is an ideal eukaryotic cell model, we would like to clarify the molecular mechanism by which cells maintain homeostasis of energy metabolism while responding to various environmental changes.

On-going projects

  1. ATP homeostasis and cellular ageing
  2. Visualization of intracellular ATP dynamics
  3. Granule-like assembly of de novo purine metabolic enzymes
  4. Cell death and cellular GTP level

 

Keywords

yeast, metabolism, signal transduction, ATP, energy metabolism, purine metabolism, TOR complex

Select References

  1. Hoshino S. et al., (2021) Commun. Biol. 4(1)
  2. Takaine M. et al., (2019) J Cell Sci. 132(8)
  3. Ito H. et al., (2019) BBRC 511(4)

 

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