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群馬大学 生体調節研究所

アクセス

Metabolic Regulation and Genetics

Professor:Takashi Nishimura
t-nishimura*gunma-u.ac.jp
(*=@)
Lab Homepage

 

Member

Professor: Takashi Nishimura
Assistant Professor: Chihiro Mogi

Research

Appropriate dietary balance and metabolic regulations vary with each life stage from birth to aging. Using the fruit fly, Drosophila melanogaster, as a model organism, our laboratory aims to understand the basic principles of metabolic homeostasis throughout life history. In particular, we are focusing on the nutritional response immediately after birth, metabolic homeostasis specific to the transition from growth to sexual maturity, and changes in physiological functions associated with aging. Based on these basic researches, we will contribute to the understanding of the pathogenesis and pathophysiology of diseases caused by the breakdown of endocrine hormones and metabolic homeostasis.

On-going projects

  1. Local regulation of insulin function by insulin-binding proteins
  2. Regulatory mechanisms of glycogen and lipid metabolism specific to maturation
  3. Elucidation of the molecular basis of postnatal metabolic adaptation

Keywords

Drosophila、Metabolic homeostasis、Nutritional response、Sugar metabolism、Insulin、Endocrine hormone、Steroid hormone、Growth、Maturation、Aging

Select References

  1. Sasaki A. et al. (2021) Nat Metabolism. doi: 10.1038/s42255-021-00375-x.
  2. Yamada T. et al. (2020) Nat Metabolism. 2(10):1096-1112.
  3. Nishimura T. (2020) Curr Biol. 30(18):3624-3632.
  4. Matsushita R. et al. (2020) Commun Biol. 3(1):170.
  5. Hironaka K. et al. (2019) iScience. 20:348-358.
  6. Yamada T. et al. (2019) Development. 146(8):dev176149.
  7. Yamada T. et al. (2018) Development. 145(6):dev158865.
  8. Okamoto N. et al. (2015) Dev Cell. 35(3):295-310.
  9. Matsuda H. et al. (2015) J Biol Chem. 290(2):1244-1255.
  10. Okamoto N. et al. (2013) Genes Dev. 27(1):87-97.

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