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群馬大学 生体調節研究所

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Metabolic Regulation and Genetics

Professor:NISHIMURA Takashi
t-nishimura*gunma-u.ac.jp
(*=@)
Lab Homepage
https://sites.google.com/view/nishimura-lab/

 

Member

Professor: NISHIMURA Takashi
Assistant Professor: YOSHINARI Yuto
Technical Officer: TOBO Masayuki
Technical Assistant: Chisei Arakawa

Professor: NISHIMURA Takashi Assistant Professor: YOSHINARI Yuto Technical Officer: TOBO MasayukiProfessor: NISHIMURA Takashi Assistant Professor: YOSHINARI Yuto Technical Officer: TOBO MasayukiProfessor: NISHIMURA Takashi Assistant Professor: YOSHINARI Yuto Technical Officer: TOBO Masayuki●87068706

Research

Appropriate dietary balance and metabolic regulations vary with each life stage from birth to aging. Using the fruit fly, Drosophila melanogaster, as a model organism, our laboratory aims to understand the basic principles of metabolic homeostasis throughout life history. In particular, we are focusing on the nutritional response immediately after birth, metabolic homeostasis specific to the transition from growth to sexual maturity, and changes in physiological functions associated with aging. Based on these basic researches, we will contribute to the understanding of the pathogenesis and pathophysiology of diseases caused by the breakdown of endocrine hormones and metabolic homeostasis.

On-going projects

  1. Local regulation of insulin function by insulin-binding proteins
  2. Regulatory mechanisms of glycogen and lipid metabolism specific to maturation
  3. Investigation of interorgan communication regulating behavior and metabolism
  4. Technology development for metabolome and hormone analysis using mass spectrometry

Keywords

Drosophila、Metabolic homeostasis、Nutritional response、Sugar metabolism、Insulin、Endocrine hormone、Steroid hormone、Growth、Maturation、Aging

Select References

  1. Hoshino R. et al. (2023) Sci Adv. 9(8):eadd5551.
  2. Banzai K. and Nishimura T. (2023) Development. 150(1):dev201248.
  3. Sasaki A. et al. (2021) Nat Metabolism. 3(4):546-557.
  4. Yamada T et al. (2020) Nat Metabolism. 2(10):1096-1112.
  5. Nishimura T. (2020) Curr Biol. 30(18):3624-3632.
  6. Matsushita R. and Nishimura T. (2020) Commun Biol. 3(1):170.
  7. Hironaka K. et al. (2019) iScience. 20:348-358.
  8. Yamada T. et al. (2018) Development. 145(6):dev158865.
  9. Okamoto N. et al. (2015) Dev Cell. 35(3):295-310.
  10. Okamoto N. et al. (2013) Genes Dev. 27(1):87-97.

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