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群馬大学 生体調節研究所

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Diabetes and Metabolic Disorders

Professor : SHIRAKAWA Jun
jshira*gunma-u.ac.jp
(*=@)
Lab website
https://diabetes.imcr.gunma-u.ac.jp/

Member

Professor: SHIRAKAWA Jun
Associate Professor: SATO Koichi
Associate Professor: ISHIDA Emi
Assistant Professor: INOUE Ryota
Assistant Professor: MATSUNAGA Kohichi
Technical Officer: HAGIWARA Yoshihiko
Technical Assistant: NISHIYAMA Chizu
Technical Assistant: FUKUSHIMA Setsuko
Administrative Assistant: MURAI Fuyumi
Graduate student : TSURUMOTO Asuka
Graduate student: NISHIYAMA Kuniyuki
Graduate student: TSUNO Takahiro
Undergraduate student : SAKAI Chisato
Undergraduate student : OBATA Yusuke
Undergraduate student : MATSUMURA Anzu
Visiting Researcher: HIRANO Hisashi
Visiting Researcher: OSANAI Tatsuya

Professor: SHIRAKAWA Jun Associate Professor: SATO Koichi Associate Professor: ISHIDA Emi Assistant Professor: INOUE Ryota Assistant Professor: MATSUNAGA Kohichi Technical Officer: HAGIWARA YoshihikoProfessor: SHIRAKAWA Jun Associate Professor: SATO Koichi Associate Professor: ISHIDA Emi Assistant Professor: INOUE Ryota Assistant Professor: MATSUNAGA Kohichi Technical Officer: HAGIWARA YoshihikoProfessor: SHIRAKAWA Jun Associate Professor: SATO Koichi Associate Professor: ISHIDA Emi Assistant Professor: INOUE Ryota Assistant Professor: MATSUNAGA Kohichi Technical Officer: HAGIWARA Yoshihiko●81298129

Research

The lab is investigating the pathophysiology of pancreatic islets and other metabolic organs. We are using integrating top-down and bottom-up approaches to identify the clues to the development of therapeutic strategies for diabetes or metabolic disorders. Areas of interest include islet cell growth factors, cell fate determination in endocrine pancreas, metabolic inflammation, inter-organ communication, plasticity of human islet cells, and diabetes therapy.

 

On-going projects

  1. Regulation of α-cell and β-cell functions in human islets
  2. Inflammation and organ networks to modulate metabolism
  3. Pathophysiology of metabolic disorders in human and animal models
  4. Reverse translational research (rTR) from medical big data and human genetics
  5. Drug repositioning for treatment of metabolic disorders and cancer

Keywords

pancreatic β cells, human islets, biomarkers, humoral factors, organ networks, cell division, apoptosis, transdifferentiation, diabetes, obesity, fatty liver, adipose tissue inflammation.

Select References

  1. Arai M. et al. (2023) Thyroid. in press.
  2. Shirakawa J (2022) Cell Rep. 41(1):111436.
  3.  Miyashita D. et al. (2022) iScience. 25(12):105662.
  4. Inoue R. et al. (2022) iScience. 25(7):104603, 2022.
  5.  Shirakawa J. et al. (2020) Diabetologia. 63(3):577-587.
  6.  Ji Y. et al. (2019) Nat Immunol. 20(6):677-686.
  7.  Jungtrakoon P. et al. (2019) Diabetes. 68(5):1084-1093.
  8.  Arai M. et al. (2018) Diabetes Care. 41(9):e130-e132.
  9. Kawamori D. et al. (2017) Diabetologia 60(8):1442-1453.
  10.  Shirakawa J. et al. (2017) Cell Metab. 25(4):868-882.

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