• 2026.04.10
• Press
• Joint
• 論文発表
• Metformin suppresses β-cell apoptosis under ER stress by inhibiting protein translation
• Ryota Inoue, Kazuki Tajima, Tomoko Okuyama, Chisato Sakai, Tamaki Kanno, Meng Zou, Mayu Kyohara, Kohichi Matsunaga, Takahiro Tsuno, Junyu Luo, Emi Ishida, Shin-ichi Horike, Tohko Hirano, Noriaki Arakawa, Tatsuya Kin, A.M. James Shapiro, Yasuo Terauchi, Hideru Obinata, Hisashi Hirano, and Jun Shirakawa. (Laboratory of Diabetes and Metabolic Disorders, Yokohama City University, University of Alberta)（代謝疾患医科学分野）

• 2025.12.26
• Press
• 論文発表
• First Evidence That Non-DNA Sequence Alterations in Sperm Influence Offspring Phenotypes
• Takuro Horii, Sumiyo Morita, Shinjiro Hino, Yuko Hino, Hiroto S Fukushima, Ryosuke Kobayashi, Mika Kimura, Mitsuyoshi Nakao, Yoichi Mizukami, Azusa Inoue and Izuho Hatada (Lab. of Genome Science, IMEG, Kumamoto Univ., RIKEN IMS, Yamaguchi Univ. Sci. Res. Ctr.)（Genome Science）

• 2025.10.06
• Press
• Joint
• 論文発表
• Regulatory roles of IGF2R in insulin secretion and adaptive β-cell proliferation
• Shirakawa J, et al. (Lab of Diabetes and Metabolic Disorders)（代謝疾患医科学分野）

• 2025.08.20
• Press
• 論文発表
• Mucin responsiveness of a next-generation probiotic revealed in a human intestinal model: Gene expression changes of Akkermansia in co-culture with human intestinal organoids.
• Moemi Matsuzaki, Atsuki Imai, Kota Yanagisawa, Tsukasa Oda, Hideo Satsu, Nobuo Sasaki, Eiji Miyauchi (Lab. of Mucosal Ecosystem Design, Maebashi Institute of Technology Univ.)（粘膜エコシステム制御分野）

• 2025.07.28
• Press
• Joint
• 論文発表
• Imeglimin suppresses glucagon secretion and induces a loss of α-cell identity
• Shirakawa J, et al. (Lab of Diabetes and Metabolic Disorders)（代謝疾患医科学分野）

• 2025.07.14
• Press
• Joint
• 論文発表
• Adenylosuccinate mediates imeglimin-induced proliferative and antiapoptotic effects in β-cells.
• Shirakawa J, et al. (Lab of Diabetes and Metabolic Disorders)（代謝疾患医科学分野）

• 2025.07.14
• Press
• 論文発表
• FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons
• Kohno D, Kawabata-Iwakawa R, Ichinose S, Suyama S, Ohashi K, Ariyani W, Sadakata T, Yokota-Hashimoto H, Kobayashi R, Horii T, Susanti VY, Konno A, Tsuneoka H, Yoshikawa C, Matsui S, Harada A, Yada T, Hatada I, Hirai H, Nishiyama M, Sasaki T, Kitamura T.（Metabolic Signal）

• 2025.07.07
• Press
• 論文発表
• Clarifying the effect of probiotics in the experimental system that reproduces the human intestinal environment. New evaluation system for health food and drug development
• Akira Sen, Atsuki Imai, Eiji Miyauchi, Kota Yanagisawa, Tsukasa Oda, Fuki Sasaki, ShintaroUchida, Takuhisa Okada, Takehiko Yokobori, Hiroshi Saeki, Toshitaka Odamaki, and Nobuo Sasaki（Lab. for Mucosal Ecosystem Design, Morinaga Milk Industry Co. Ltd., Graduate School of Medicine, Gunma University, Gunma University Initiative for Advanced Research）（粘膜エコシステム制御分野）

• 2025.05.01
• Press
• 論文発表
• Phase separation of the PRPP amidotransferase into dynamic condensates promotes de novo purine synthesis in yeast
• Masak Takaine1,*, Rikuri Morita2, Yuto Yoshinari３ and Takashi Nishimura３ (1.GIAR, Gunma University, Maebashi, Japan, IMCR, Gunma University, Maebashi, Japan: 2. Center for Computational Sciences, University of Tsukuba, Ibaraki, Japan: 3. Laboratory of Metabolic Regulation and Genetics, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan; *Corresponding Author)（個体代謝生理学分野）

• 2025.04.03
• Press
• 論文発表
• Dopaminergic neurons in the paraventricular hypothalamus extend the food consumption phase
• Winda Ariyani, Chiharu Yoshikawa, Haruka Tsuneoka, Izuki Amano, Itaru Imayoshi, Hiroshi Ichinose, Chiho Sumi-Ichinose, Noriyuki Koibuchi, Tadahiro Kitamura, Daisuke Kohno (Metabolic Signal Research Center, Department of Integrative Physiology, Kyoto University, Tokyo Institute of Technology, Fujita Health University)（Metabolic Signal）