Professor： SASAKI Nobuo
nosasaki*gunma-u.ac.jp
(*=@)
Lab Homepage
https://sites.google.com/gunma-u.ac.jp/nob-sasaki-lab/
Member
Professor: SASAKI Nobuo
Associate Professor: MIYAUCHI Eiji
Assistant Professor: ODA Tsukasa
Assistant Professor: MOGI Chiro
Assistant Professor(Metabolomics Research Unit): ITO Doshun
Technical Officer: HAGIWARA Yasuhiko
Technical Assistant: TAKAGI Wakana
Technical Assistant: KISHI Megumi
Administrative Assistant: TAKAHASHI Etsuko
Collaborative Researcher: GOTO Nanami
Visiting Researcher: SEN Akira
Graduate Student: YANAGISAWA Kota
Graduate Student: FURUKAWA Riho
Graduate Student: KONDO Nozomi
Graduate Student: HASEGAWA Miori
Graduate Student: KAITO Misaki
Graduate Student: NINOMIYA Karin
Graduate Student: MATSUZAKI Moaemi
Undergraduate student: UCHIYAMA Kota
Undergraduate student: OMOTEGAWA Kento
Undergraduate student: SAWASE Riko
Undergraduate student: NOMOTO Nao
Undergraduate student: NAKAMURA Makishi
Undergraduate student: MORI Ryotaro
Undergraduate student: TAKANO Kaede
Undergraduate student: TAKAHASHI Yuito
Research
Our stomach and intestine continuously produce gastrointestinal hormones that are important for vital activities such as digestion, absorption and controlling blood glucose level. Dysregulation of gastrointestinal hormone with aging causes several diseases including atrophic gastritis, small intestinal bacterial overgrowth (SIBO) or colorectal cancer. Although quality of gastrointestinal hormones is determined by enteroendocrine cells which are derived from intestinal stem cells, the regulatory mechanism of enteroendocrine cells differentiation is still largely unknown. To elucidate organization of stem cell hierarchy at the gastrointestinal tract, we have focused on not only cell-cell contact, but also host cells-commensal bacteria interaction. Our final goal is to realize the society that mucosal ecosystem can be “designed freely” through finding functional bacteria acted as probiotics manner.
On-going projects
- Analysis of molecular basis underlying interaction between adult tissue stem cells and gut bacteria
- Understanding disease-mechanism caused by bacterial infection
- Development of human tissue and organ using organoid culture system
Keywords
Gut microbiota, Adult tissue stem cell, Organoid, GLP-1, Type 1 diabete, colorectal cancer, infection disease
Select References
1. Oda et al. (2023) Cell Prolif. 56(6):e13398.
2. Miyauchi et al. (2023) Nat Rec Immunol. 23(1): 9-23
3. Miyauchi et al. (2022) Sci Rep. 12(1):1758
4. Takeuchi, Miyauchi et al (2021) Nature 595(7868): 560-564
5. Sasaki et al. (2020) Gastroenterology 159(1): 338-390
6. Nanki*, Fujii* et al. (2020) Nature 577(7789): 254-259 (*: equally contribution)
7. Roerink*, Sasaki* et al (2018) Nature 556(7702): 457-462 (*: equally contribution)
8. Drost et al. (2017) Science 358(6360): 234-238
9. Blokzijl et al. (2016) Nature 538(7624): 260-264
10. Sasaki et al. (2016) PNAS 113(37):E5399-5407
