Research

Generally, the risk of developing metabolic diseases such as diabetes and obesity increases with age. However, type 1 diabetes is more common in childhood, and fatty liver disease has been rising at a young age in recent years, it is necessary to conduct a wide range of studies over all generations to understand the pathogenesis of metabolic disease fundamentally. Therefore, this unit collaborates with the University Hospital and clinic to analyze metabolites in human patient samples (tissue, blood, stool, etc.) from children, adolescents, and elderly persons. The results of this research are expected to lead to the identification of novel therapeutic and drug targets by proving metabolic changes in the body associated with disease onset.

On-going projects

1. Analysis of metabolites involved in homeostasis maintenance in adult mice
2. Analysis of the relationship between physical exercise and gut microbiota during adolescence and adulthood
3. Analysis of the relationship between metabolic regulation and ppGpp phosphatase during early development

Keywords

Metabolism, Metabolomics, LC-MS, Signal Transduction, Stress Response

Select References

1.  Ito K. et al. (2022) PCP. 63(7): 919-931.
2.  Ito D. et al. (2020) Commun. Biol. 3(1).
3.  Ono S. et al. (2020) PCP. 61(12) 2077-2086.