Professor: HATTORI Naoko
naoko.hattori*gunma-u.ac.jp
(*=@)
Lab Homepage
https://metabolic-system.imcr.gunma-u.ac.jp/laboratory-of-integrative-metabolic-regulation/
Member
Professor: HATTORI Naoko
Assistant Professor: YAMAGISHI Genki
Technical Officer: TOBO Masayuki
Technical Assistant: IZAWA Yumi
Technical Assistant: OHATA Yoko
Undergraduate student : KASAHARA Fumika
Undergraduate student: KIMURA Kozue
Research
Dysregulation of cell identity leads to disruption of homeostasis, becoming an underlying cause of disease development. We focus on epigenetics, which plays crucial roles in cell fate determination, and aim to unravel the pathological mechanisms underlying various diseases, including diabetes, cancer, and allergies. Through an integrative analysis of molecules, cultured cells, and mouse models, we are investigating the molecular basis of disease onset and developing novel therapeutic strategies.
On-going projects
- Epigenomic alterations involved in disease onset and development of epigenetic therapies
- Novel metabolic regulatory mechanisms for the treatment of metabolic diseases
- Regulation of cancer drug sensitivity via fatty acid metabolism
- Mechanisms of cancer drug resistance driven by HER2 mutations
Keywords
Epigenetics, cancer, obesity/diabetes, fatty acid metabolism, drug sensitivity
Select References
- Hattori N, et al. (2025) Front Oncol 15:1419877. doi: 10.3389/fonc.2025.1419877.
- Okunishi K, et al. (2024) Allergy 79(7):1992-1995. doi: 10.1111/all.16087.
- Shimomura K, et al. (2023) Nat Commun 14(1):6415. doi: 10.1038/s41467-023-42228-z.
- Yamagishi G, et al. (2022) Zool Sci 39(5):419–430. doi: 10.2108/zs220038.
- Hattori N, et al. (2021) Br J Cancer 125(12):1647-1656. doi: 10.1038/s41416-021-01571-y.
- Zong L*, Hattori N*, et al. (2019) Oncogene 38(26):5281-5293. doi: 10.1038/s41388-019-0792-8.
- Yamagishi G, et al. (2016) Gen Comp Endocrinol 225:197–211. doi: 10.1016/j.ygcen.2015.10.013.
- Hattori N, et al (2013) Nucleic Acids Res 41:7231-7239. doi: 10.1093/nar/gkt528.
