Professor: HATTORI Naoko
naoko.hattori*gunma-u.ac.jp
(*=@)
Lab Homepage
https://metabolic-system.imcr.gunma-u.ac.jp/laboratory-of-integrative-metabolic-regulation/
Member
Professor: HATTORI Naoko
Assistant Professor: YAMAGISHI Genki
Technical Officer: TOBO Masayuki
Technical Assistant: IZAWA Yumi
Undergraduate student : KASAHARA Fumika
Undergraduate student: KIMURA Kozue
Research
Dysregulation of cell identity leads to disruption of homeostasis, becoming an underlying cause of disease development. We focus on epigenetics, which plays crucial roles in cell fate determination, and aim to unravel the pathological mechanisms underlying various diseases, including diabetes, cancer, and allergies. Through an integrative analysis of molecules, cultured cells, and mouse models, we are investigating the molecular basis of disease onset and developing novel therapeutic strategies.
On-going projects
- Identification of epigenomic alterations involved in disease onset and the development of epigenetic therapies
- Exploration of novel metabolic regulatory mechanisms for therapeutic development
- Regulation of drug sensitivity by fatty acid metabolism through alterations in cellular membrane composition
Keywords
Epigenetics, cancer, obesity/diabetes, cell membrane
Select References
- Hattori N, et al. (2025) Front Oncol 15:1419877. doi: 10.3389/fonc.2025.1419877.
- Okunishi K, et al. (2024) Allergy 79(7):1992-1995. doi: 10.1111/all.16087.
- Shimomura K, et al. (2023) Nat Commun 14(1):6415. doi: 10.1038/s41467-023-42228-z.
- Yamagishi G, et al. (2022) Zool Sci 39(5):419–430. doi: 10.2108/zs220038.
- Hattori N, et al. (2021) Br J Cancer 125(12):1647-1656. doi: 10.1038/s41416-021-01571-y.
- Zong L*, Hattori N*, et al. (2019) Oncogene 38(26):5281-5293. doi: 10.1038/s41388-019-0792-8.
- Yamagishi G, et al. (2016) Gen Comp Endocrinol 225:197–211. doi: 10.1016/j.ygcen.2015.10.013.
- Hattori N, et al (2013) Nucleic Acids Res 41:7231-7239. doi: 10.1093/nar/gkt528.
