{"id":9743,"date":"2021-12-14T10:11:45","date_gmt":"2021-12-14T01:11:45","guid":{"rendered":"https:\/\/www.imcr.gunma-u.ac.jp\/?p=9743"},"modified":"2022-03-28T16:48:28","modified_gmt":"2022-03-28T07:48:28","slug":"20211220%e5%86%85%e5%88%86%e6%b3%8c%e3%83%bb%e4%bb%a3%e8%ac%9d%e5%ad%a6%e3%80%80%e5%85%b1%e5%90%8c%e5%88%a9%e7%94%a8%e5%85%b1%e5%90%8c%e7%a0%94%e7%a9%b6%e6%8b%a0%e7%82%b9%e3%82%bb%e3%83%9f%e3%83%8a","status":"publish","type":"post","link":"https:\/\/www.imcr.gunma-u.ac.jp\/?p=9743","title":{"rendered":"[20211220]\u5185\u5206\u6ccc\u30fb\u4ee3\u8b1d\u5b66\u3000\u5171\u540c\u5229\u7528\u5171\u540c\u7814\u7a76\u62e0\u70b9\u30bb\u30df\u30ca\u30fc\uff082021\u5e7412\u670820\u65e5\u958b\u50ac\uff09\u751f\u6d3b\u7fd2\u6163\u75c5\u89e3\u6790\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u5171\u50ac"},"content":{"rendered":"<p>2021\u5e7412\u670820\u65e516\u6642\u3088\u308a\u751f\u4f53\u8abf\u7bc0\u7814\u7a76\u6240\u5185\u5206\u6ccc\u30fb\u4ee3\u8b1d\u5171\u540c\u5229\u7528\u5171\u540c\u7814\u7a76\u62e0\u70b9\u30bb\u30df\u30ca\u30fc\u3092\u73fe\u5730\u8b1b\u6f14\u304a\u3088\u3073\u30aa\u30f3\u30e9\u30a4\u30f3 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srcset=\"https:\/\/www.imcr.gunma-u.ac.jp\/cms_imcr\/wp-content\/uploads\/2021\/12\/b8c1cb7a5280b21cdc8404a4656e6069-208x300.jpg 208w, https:\/\/www.imcr.gunma-u.ac.jp\/cms_imcr\/wp-content\/uploads\/2021\/12\/b8c1cb7a5280b21cdc8404a4656e6069-709x1024.jpg 709w, https:\/\/www.imcr.gunma-u.ac.jp\/cms_imcr\/wp-content\/uploads\/2021\/12\/b8c1cb7a5280b21cdc8404a4656e6069.jpg 720w\" sizes=\"auto, (max-width: 208px) 100vw, 208px\" \/><\/a><\/p>\n<p>\u300c\u30a8\u30d4\u30b2\u30ce\u30e0\u30c0\u30a4\u30ca\u30df\u30af\u30b9\u3092\u4ecb\u3057\u305f\u8840\u7ba1\u6d3b\u6027\u5316\u907a\u4f1d\u5b50\u7fa4\u306e\u8a98\u5c0e\u3068\u30c0\u30a6\u30f3\u75c7\u95a2\u9023\u56e0\u5b50\u306b\u3088\u308b\u6297\u304c\u3093\u30fb\u6297\u751f\u6d3b\u7fd2\u6163\u75c5\u5236\u5fa1\u300d<br \/>\u30fb\u8b1b\u5e2b\uff1a\u5357\u3000\u656c \u5148\u751f<br \/>\u718a\u672c\u5927\u5b66\u3000\u751f\u547d\u8cc7\u6e90\u7814\u7a76\u652f\u63f4\u30bb\u30f3\u30bf\u30fc<br \/>\u5927\u5b66\u9662\u751f\u547d\u79d1\u5b66\u7814\u7a76\u90e8\u5206\u5b50\u8840\u7ba1\u5236\u5fa1\u5206\u91ce\u3000\u6559\u6388<br \/>\u30fb\u65e5\u6642\uff1a2021\u5e7412\u670820\u65e5\uff08\u6708\uff0916:00\uff5e17:00<br \/>\u30fb\u958b\u50ac\u65b9\u6cd5\uff1a\u8b1b\u6f14\uff08\u751f\u4f53\u8abf\u7bc0\u7814\u7a76\u6240\uff11\u968e \u4f1a\u8b70\u5ba4\uff09\u304a\u3088\u3073\u30aa\u30f3\u30e9\u30a4\u30f3\uff08zoom\u958b\u50ac\uff09<br \/>\u30fb\u7533\u8fbc\u65b9\u6cd5\uff1a12\u670820\u65e5\uff08\u6708\uff09\u6b63\u5348\u307e\u3067\u306b\u6240\u5c5e\u30fb\u6c0f\u540d\u30fb\u30bb\u30df\u30ca\u30fc\u958b\u50ac\u65e5\u3092\u4e0b\u8a18\u306e\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\u3067\u5165\u529b\u3057\uff0c<br \/>https:\/\/docs google com\/forms\/d\/e\/ 1 FAIpQLSeAArh 651 EqQJA 1 taK_ceH 0 kc<br \/>zsmUYmZtKJzRoauIV 9 Q 0 n 2 oQ\/viewform<br \/>\u30fb\u9023\u7d61\u5148\uff1a\u7a32\u57a3\u3000\u751f\u4f53\u8abf\u7bc0\u7814\u7a76\u6240 \u4ee3\u8b1d\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u5206\u91ce\uff08\u5185\u7dda 8880\uff09<\/p>\n<p>\u5faa\u74b0\u6052\u5e38\u6027\u306f\u3001\u708e\u75c7\uff65\u8840\u7ba1\u65b0\u751f\uff65\u51dd\u56fa\u306e\u5404\u30b9\u30c6\u30c3\u30d7\u304c\u968e\u5c64\u7684\u306b\u7d44\u7e54\u7684\u306b\u884c\u308f\u308c\u308b\u3053\u3068\u3067\u6b63\u5e38\u306b\u6a5f\u80fd\u3059\u308b\u3002\u7279\u306b\u8840\u7ba1\u5185\u76ae\u5236\u5fa1\u304c\u7269\u8cea\u900f\u904e\u6027\u3001\u6b63\u5e38\u767a\u751f\u3084\u816b\u760d\u767a\u751f\u306e\u8981\u3068\u8003\u616e\u3055\u308c\u3066\u304a\u308a\u3001\u6211\u304c\u56fd\u306e\u751f\u6d3b\u7fd2\u6163\u75c5\u3092\u542b\u3081\u305f\u4e09\u5927\u75be\u60a3\u6291\u5236\u306b\u5411\u3051\u3066\u306e\u91cd\u8981\u306a\u30b9\u30c6\u30c3\u30d7\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u305d\u3053\u3067\u5148\u305a\u3001\u708e\u75c7\u3092\u4f34\u3046\u8840\u7ba1\u65b0\u751f\u56e0\u5b50\u306e\u4ee3\u8868\u3068\u3057\u3066 VEGF \u306b\u7740\u76ee\u3057\u3001\u5185\u76ae\u7d30\u80de\u306b\u304a\u3051\u308b VEGF \u30b7\u30b0\u30ca\u30eb\u3067\u306e\u30b2\u30ce\u30e0\uff65\u30a8\u30d4\u30b2\u30ce\u30e0\u52d5\u614b\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u30b7\u30b0\u30ca\u30eb\u3092\u53d7\u3051\u3066\uff15\u5206\u5f8c\u306b\u306f\u30af\u30ed\u30de\u30c1\u30f3\u69cb\u9020\u5909\u5316\u304c\u751f\u3058\u3001NFAT \u7d4c\u8def\u304c\u7279\u7570\u7684\u306b\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3001\u8840\u7ba1\u65b0\u751f\u306b\u5fc5\u9808\u306a\u5168\u3066\u306e\u5373\u6642\u578b\u8ee2\u5199\u56e0\u5b50\u7fa4\u306e\u767a\u73fe\u5236\u5fa1\u9818\u57df\u306b\u7279\u5fb4\u4ed8\u3051\u3089\u308c\u308b Bivalent histone mark \u306e\u5b58\u5728\u304c\u898b\u51fa\u3055\u308c\u305f\u3002VEGF \u523a\u6fc0 15 \u5206\u5f8c\u306b\u306f\u3001Bivalent \u9818\u57df\u306b\u6d3b\u6027\u5316\u30dd\u30ea\u30b3\u30fc\u30e0(PRC)1.3\u304c\u6fc3\u7e2e\u3057\u3066 H2AK119Ub \u30ec\u30d9\u30eb\u304c\u6e1b\u5c11\u3057\u3001H3K27me3 \u30d6\u30ec\u30fc\u30ad\u6a5f\u69cb\u304c\u30ad\u30e3\u30f3\u30bb\u30eb\u3055\u308c\u3001\u305d\u306e\u5f8c PRC1.3 \u304b\u3089canonical PRC1\u306b\u7f6e\u63db\u3059\u308b60\u5206\u4ee5\u5185\u306b\u30af\u30ed\u30de\u30c1\u30f3\u304c\u9589\u3058\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u53c8 NFAT \u3068 MLL3\/4 adaptor-PTIP\u304c\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u304b\u3089\u3001NFAT\u914d\u5217\u8a8d\u8b58\u80fd\u3092\u4ecb\u3057\u3066\u3053\u306e Bivalent\u9818\u57df\u306b MLL3\/4 \u8907\u5408\u4f53\u304c\u6fc3\u7e2e\u3057\u30a2\u30af\u30bb\u30eb\u30de\u30fc\u30af\u3092\u5897\u5e45\u3055\u305b\u308b\u52d5\u7684\u306a\u8ee2\u5199\u539f\u7406\u304c\u793a\u3055\u308c\u305f\u3002\u66f4\u306bVEGF \u523a\u6fc0\uff11\u6642\u9593\u5f8c\u306b\u306f NFAT \u30b7\u30b0\u30ca\u30eb\u306e\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u963b\u5bb3\u80fd\u3092\u6709\u3059\u308b\u30c0\u30a6\u30f3\u75c7\u56e0\u5b50 (DSCR)-1 \u304c\u8a98\u5c0e\u3055\u308c\u308b\u3002\u305d\u3053\u3067 DSCR-1 \u53ca\u3073\u30c0\u30a6\u30f3\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u8840\u7ba1\u5236\u5fa1\u89e3\u6790\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u30c0\u30a6\u30f3\u75c7\u306e\u56fa\u5f62\u304c\u3093\u62b5\u6297\u6027\u306e\u307f\u306a\u3089\u305a\u3001\u6297\u52d5\u8108\u786c\u5316\u6a5f\u80fd\u3082\u518d\u73fe\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3002\u66f4\u306b DSCR-1 \u304c\u306a\u3044\u3068\u809d\u81d3\u306e\u708e\u75c7\u304c\u4ea2\u9032\u3057\u3001\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u306b\u3088\u308a\u91cd\u7be4\u306a\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3092\u5448\u3059\u308b\u3053\u3068\u3001\u305d\u306e\u7d50\u679c\u52a0\u9f62\u306b\u4f34\u3044\u8102\u80aa\u816b\u3084\u89d2\u819c\u6df7\u6fc1\u3092\u793a\u3059\u3053\u3068\u3092\u65b0\u305f\u306b\u898b\u51fa\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u5b66\u8853\u5c55\u958b\u304c\u30c0\u30a6\u30f3\u75c7\u306f\u3082\u3068\u3088\u308a\u3001\u52a0\u9f62\uff65\u751f\u6d3b\u7fd2\u6163\u75c5\u3084\u304c\u3093\u306b\u5bfe\u3059\u308b\u65b0\u898f\u6cbb\u7642\uff65\u4e88\u9632\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u7e4b\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/p>\n<p>\u30dd\u30b9\u30bf\u30fc\u306f\u3053\u3061\u3089 \u2192 <a href=\"https:\/\/www.imcr.gunma-u.ac.jp\/cms_imcr\/wp-content\/uploads\/2021\/12\/b8c1cb7a5280b21cdc8404a4656e6069.pdf\" target=\"_blank\" rel=\"noopener\">2021\u5e74\u5ea6 \u62e0\u70b9\u30bb\u30df\u30ca\u30fc \u30d5\u30e9\u30a4\u30e4\u30fc \u5357\u656c\u5148\u751f TSTI (003)<\/a><\/p>\n<p><a href=\"https:\/\/www.imcr.gunma-u.ac.jp\/cms_imcr\/wp-content\/uploads\/2021\/12\/b8c1cb7a5280b21cdc8404a4656e6069.jpg\" data-rel=\"lightbox-image-1\" data-rl_title=\"\" data-rl_caption=\"\" title=\"\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-9755\" src=\"https:\/\/www.imcr.gunma-u.ac.jp\/cms_imcr\/wp-content\/uploads\/2021\/12\/b8c1cb7a5280b21cdc8404a4656e6069-208x300.jpg\" alt=\"\" width=\"208\" height=\"300\" srcset=\"https:\/\/www.imcr.gunma-u.ac.jp\/cms_imcr\/wp-content\/uploads\/2021\/12\/b8c1cb7a5280b21cdc8404a4656e6069-208x300.jpg 208w, https:\/\/www.imcr.gunma-u.ac.jp\/cms_imcr\/wp-content\/uploads\/2021\/12\/b8c1cb7a5280b21cdc8404a4656e6069-709x1024.jpg 709w, 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