{"id":7985,"date":"2020-06-25T11:50:32","date_gmt":"2020-06-25T02:50:32","guid":{"rendered":"https:\/\/www.imcr.gunma-u.ac.jp\/?p=7985"},"modified":"2020-07-09T11:59:37","modified_gmt":"2020-07-09T02:59:37","slug":"%e7%b4%b0%e8%83%9e%e3%81%aeph%e3%81%8c%e8%83%9a%e7%99%ba%e7%94%9f%e3%82%92%e9%a7%86%e5%8b%95%e3%81%99%e3%82%8b%e3%83%a1%e3%82%ab%e3%83%8b%e3%82%ba%e3%83%a0%e3%82%92%e7%99%ba%e8%a6%8b%e7%b4%b0%e8%83%9e","status":"publish","type":"post","link":"https:\/\/www.imcr.gunma-u.ac.jp\/?p=7985","title":{"rendered":"\u7d30\u80de\u306epH\u304c\u80da\u767a\u751f\u3092\u99c6\u52d5\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u767a\u898b"},"content":{"rendered":"<p>\u672c\u7814\u7a76\u6240\u306e\u837b\u6cbc\u653f\u4e4b\u52a9\u6559\u3001\u5143\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u3000\u64ad\u78e8\u6709\u5e0c\u5b50\u7814\u7a76\u54e1\u3001\u7fa4\u99ac\u5927\u5b66\u3000\u77f3\u8c37\u592a\u6559\u6388\uff08\u5927\u962a\u5927\u5b66\u517c\u4efb\uff09\u3001\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u3000\u30aa\u30ea\u30d3\u30a8\u30d7\u30eb\u30ad\u30a8\u6559\u6388\u3089\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u7d30\u80de\u306epH\u304c\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306a\u52d5\u7269\u80da\u767a\u751f\u3092\u652f\u3048\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u3001\u305d\u306e\u6210\u679c\u306f2020\u5e746\u670824\u65e516:00\uff08\u30ed\u30f3\u30c9\u30f3\u6642\u9593\uff09\u306b\u82f1\u79d1\u5b66\u8a8c\u300c\u30cd\u30a4\u30c1\u30e3\u30fc\u300d\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306f\u751f\u547d\u73fe\u8c61\u306e\u4e2d\u5fc3\u3067\u3042\u308a\u3001\u69d8\u3005\u306a\u5206\u91ce\u3067\u7814\u7a76\u306f\u9032\u3093\u3067\u304a\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u52d5\u7269\u306e\u4f53\u3065\u304f\u308a\uff08\u80da\u767a\u751f\uff09\u306b\u304a\u3051\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u5f79\u5272\u306f\u307b\u3068\u3093\u3069\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u6211\u3005\u306f\u904e\u53bb\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u52d5\u7269\u80da\u5f8c\u7aef\u90e8\uff08\u5c3e\u82bd\u9818\u57df\uff09\u3067\u89e3\u7cd6\u7cfb\u304c\u52fe\u914d\u3092\u5f62\u6210\u3057\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u52fe\u914d\u5f62\u6210\u3092\u4fc3\u304c\u3059\u3053\u3068\u3067\u3001\u80da\u306e\u5f8c\u65b9\u30d1\u30bf\u30fc\u30f3\u5f62\u6210\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u5206\u5b50\u8a73\u7d30\u306f\u4e0d\u660e\u306e\u307e\u307e\u3067\u3057\u305f(Oginuma et al.,Developmental cell, 2007)\u3002\u672c\u7814\u7a76\u306f\u3001\u7d30\u80de\u5185pH\u304c\u4ef2\u4ecb\u56e0\u5b50\u3068\u50cd\u304f\u4e8b\u3092\u7a81\u304d\u6b62\u3081\u307e\u3057\u305f\u3002\u6211\u3005\u306f\u30cb\u30ef\u30c8\u30ea\u80da\u306e\u5c3e\u82bd\u9818\u57df\u3068\u3001\u30d2\u30c8iPS\u7d30\u80de\u304b\u3089\u5206\u5316\u8a98\u5c0e\u3057\u305f\u30d2\u30c8\u5c3e\u82bd\u7d30\u80de\u306e\u7d30\u80de\u5185pH\u3092\u6e2c\u5b9a\u3057\u305f\u7d50\u679c\u3001\u89e3\u7cd6\u7cfb\u306e\u4e0b\u6d41\u3067\u30a2\u30eb\u30ab\u30ea\u6027pH\u306e\u52fe\u914d\u304c\u5f62\u6210\u3055\u308c\u308b\u4e8b\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u7d30\u80de\u5185pH\u306e\u30a2\u30eb\u30ab\u30ea\u5316\u304c\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u30a2\u30bb\u30c1\u30eb\u5316\u4fee\u98fe\u53cd\u5fdc\u3092\u4fc3\u9032\u3059\u308b\u4e8b\u3067\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u5236\u5fa1\u3059\u308b\u4e8b\u3092\u89e3\u660e\u81f4\u3057\u307e\u3057\u305f\u3002\u540c\u69d8\u306e\u7d30\u80de\u5185pH\u306e\u30a2\u30eb\u30ab\u30ea\u5316\u306f\u30ac\u30f3\u7d30\u80de\u306b\u304a\u3044\u3066\u3082\u89b3\u5bdf\u3055\u308c\u307e\u3059\u3002\u30ac\u30f3\u7d30\u80de\u306f\u767a\u751f\u306e\u4ee3\u8b1d\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u518d\u6d3b\u6027\u5316\u3055\u308c\u305f\u72b6\u614b\u3067\u3042\u308b\u3068\u3044\u3046\u8003\u3048\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u672c\u7814\u7a76\u306f\u307e\u3055\u306b\u305d\u306e\u8a3c\u62e0\u3092\u63d0\u793a\u3057\u305f\u7814\u7a76\u3067\u3059\u3002<\/p>\n<p>\u96d1\u8a8c\u540d\uff1a\u300cNature\u300d\uff086\u670824\u65e5\u30aa\u30f3\u30e9\u30a4\u30f3\uff09<br \/>\u30bf\u30a4\u30c8\u30eb\uff1a&#8221;Intracellular pH Controls WNT Downstream of Glycolysis in Amniote Embryos&#8221;<br \/>\u8457\u8005\u540d\uff1a Masayuki Oginuma, Yukiko Harima, Oscar A. Tarazona, Margarete Diaz-Cuadros, Arthur Michaut, Tohru Ishitani, Fengzhu Xiong &amp; Olivier Pourqui\u00e9.<\/p>\n<p>\u8a73\u3057\u304f\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044 \u2192<a href=\"https:\/\/www.imcr.gunma-u.ac.jp\/cms_imcr\/wp-content\/uploads\/2020\/07\/5f81d1a40c7062a55f1afc361f12adfb.docx\">\u4fee\u6b63\u6848press_2020_Oginuma<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u7814\u7a76\u6240\u306e\u837b\u6cbc\u653f\u4e4b\u52a9\u6559\u3001\u5143\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u3000\u64ad\u78e8\u6709\u5e0c\u5b50\u7814\u7a76\u54e1\u3001\u7fa4\u99ac\u5927\u5b66\u3000\u77f3\u8c37\u592a\u6559\u6388\uff08\u5927\u962a\u5927\u5b66\u517c\u4efb\uff09\u3001\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u3000\u30aa\u30ea\u30d3\u30a8\u30d7\u30eb\u30ad\u30a8\u6559\u6388\u3089\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u7d30\u80de\u306epH\u304c\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306a\u52d5\u7269\u80da\u767a\u751f\u3092\u652f\u3048\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u3001\u305d\u306e\u6210\u679c\u306f [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3,61],"tags":[],"class_list":["post-7985","post","type-post","status-publish","format-standard","hentry","category-information","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.imcr.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/7985","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.imcr.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.imcr.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.imcr.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.imcr.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7985"}],"version-history":[{"count":2,"href":"https:\/\/www.imcr.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/7985\/revisions"}],"predecessor-version":[{"id":7988,"href":"https:\/\/www.imcr.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/7985\/revisions\/7988"}],"wp:attachment":[{"href":"https:\/\/www.imcr.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7985"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.imcr.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7985"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.imcr.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7985"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}