{"id":879,"date":"2015-07-03T17:48:14","date_gmt":"2015-07-03T08:48:14","guid":{"rendered":"http:\/\/www.imcr.gunma-u.ac.jp\/cms_imcr\/?page_id=879"},"modified":"2022-04-11T10:13:43","modified_gmt":"2022-04-11T01:13:43","slug":"%e7%9f%a5%e7%9a%84%e8%b2%a1%e7%94%a3","status":"publish","type":"page","link":"https:\/\/www.imcr.gunma-u.ac.jp\/?page_id=879","title":{"rendered":"\u77e5\u7684\u8ca1\u7523"},"content":{"rendered":"<h3>2011<\/h3>\n<h4>\uff27\uff30\uff32\uff11\uff11\uff19\u30a2\u30b4\u30cb\u30b9\u30c8\u4e26\u3073\u306b\u305d\u308c\u3092\u542b\u3080\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u5264\uff08\u7279\u98582011-201858\/\u7279\u958b2013-063913\uff09<\/h4>\n<p>\u767a\u660e\u8005\uff1a\u51b7\u725f\u7530\u4fee\u4e00\u3001\u4e2d\u5cf6\u5bff\u662d\u3001\u6b66\u7530\u8302\u6a39\u3001\u5c0f\u5cf6\u81f3\u3000\u3000\u51fa\u9858\u8005\uff1a\u51fa\u5149\u8208\u7523\u682a\u5f0f\u4f1a\u793e\u3001\u7fa4\u99ac\u5927\u5b66<\/p>\n<p>\u5c0f\u5cf6\u3089\u306f\u3001\u51fa\u5149\u8208\u7523\u3068\u3068\u3082\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u5264\u306b\u95a2\u3059\u308b\u7279\u8a31\u3092\u7533\u8acb\u3057\u300125\u5e74\u306b\u516c\u958b\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<h3>2010<\/h3>\n<h4>(1-1) \u7cd6\u4ee3\u8b1d\u4fc3\u9032\u5264\u4e26\u3073\u306b\u80a5\u6e80\u53ca\u3073\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\uff08\u7279\u98582005-114576\/\u7279\u958b2006-290810\uff09\uff08\u7279\u8a31\u7b2c4534039\u53f7\uff09<\/h4>\n<p>\u767a\u660e\u8005\uff1a\u4e45\u4fdd\u539f\u7985\u3001\u67f4\u7530\u5b8f\u3000\u3000\u51fa\u9858\u8005\uff1a\u7fa4\u99ac\u5927\u5b66<\/p>\n<p>\u51fa\u9858\u65e5\uff1a2005\uff08\u5e73\u621017\uff09\u5e744\u670812\u65e5\u3000\u00a0\u53d6\u5f97\u65e5\uff1a2010\uff08\u5e73\u621022\uff09\u5e746\u670825\u65e5<\/p>\n<h4>\u00a0(1-2) Method of lowering blood glucose and method of treating diabetes and obesity.\uff08\u7c73\u56fd\u51fa\u9858\uff1a11\/923,064\uff09\uff08US Patent No: 7,846,974 B2\uff09<\/h4>\n<p>\u51fa\u9858\u65e5\uff1a2007\uff08\u5e73\u621019\uff09\u5e7410\u670824\u65e5\u3000\u3000\u53d6\u5f97\u65e5\uff1a2010\uff08\u5e73\u621022\uff09\u5e7412\u67087\u65e5<\/p>\n<p>\u5f53\u7814\u7a76\u6240\u306e\u4e45\u4fdd\u539f\u3068\u67f4\u7530\u306f\u3001\u7cd6\u4ee3\u8b1d\u4fc3\u9032\u5264\u3001\u80a5\u6e80\u53ca\u3073\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306e\u65b0\u898f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u306b\u95a2\u3057\u3066\u3001\u5e73\u621022\u5e74\u306b\u56fd\u5185\u7279\u8a31\uff08\u7279\u8a31\u7b2c4534039\u53f7\uff09\u3068\u7c73\u56fd\u7279\u8a31\uff08US Patent No: 7,846,974 B2\uff09\u3092\u53d6\u5f97\u3057\u305f\u3002<\/p>\n<h4>\u6297\u30c8\u30ea\u30d1\u30ce\u30bd\u30fc\u30de\u5264\u304a\u3088\u3073\u30c8\u30ea\u30d1\u30ce\u30bd\u30fc\u30de\u75c7\u6cbb\u7642\u85ac\uff08\u7279\u98582010-163039\/\u7279\u958b2012-025671\uff09\uff08\u7279\u8a31\u7b2c5610433\u53f7\uff09<\/h4>\n<p>\u767a\u660e\u8005\uff1a\u4e45\u4fdd\u539f\u7985\u3001\u5d8b\u7530\u6df3\u5b50\u3000\u3000\u51fa\u9858\u8005\uff1a\u7fa4\u99ac\u5927\u5b66<\/p>\n<p>\u51fa\u9858\u65e5\uff1a2010\uff08\u5e73\u621022\uff09\u5e747\u670820\u65e5\u3000\u3000\u53d6\u5f97\u65e5\uff1a2014\uff08\u5e73\u621026\uff09\u5e749\u670812\u65e5<\/p>\n<p>\u5f53\u7814\u7a76\u6240\u306e\u4e45\u4fdd\u539f\u306f\u3001\u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u4fdd\u5065\u5b66\u79d1\u3068\u306e\u62e0\u70b9\u5171\u540c\u7814\u7a76\u306b\u3088\u308a\u3001\u7c98\u83cc\u7531\u6765\u306e\u7279\u5b9a\u85ac\u7406\u7269\u8cea\u3068\u305d\u306e\u8a98\u5c0e\u4f53\u304c\u3001\u30c8\u30ea\u30d1\u30ce\u30bd\u30fc\u30de\u539f\u866b\u306e\u5bbf\u4e3b\u7d30\u80de\u3078\u306e\u611f\u67d3\u3068\u7d30\u80de\u5185\u5897\u6b96\u3092\u9855\u8457\u306b\u963b\u5bb3\u3059\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u305f\uff08Nakajima-Shimada J et al. Bichem Pharmacol (2013) \u306b\u767a\u8868\uff09\u3002\u3053\u308c\u306f\u30b7\u30e3\u30fc\u30ac\u30b9\u75c5\uff08\u30a2\u30d5\u30ea\u30ab\u7720\u308a\u75c5\uff09\u3068\u3057\u3066\u30a2\u30d5\u30ea\u30ab\u3084\u5357\u7c73\u3067\u731b\u5a01\u3092\u3075\u308b\u3046\u30c8\u30ea\u30d1\u30ce\u30bd\u30fc\u30de\u75c7\u306b\u5bfe\u3059\u308b\u65b0\u898f\u6cbb\u7642\u85ac\u306e\u30ea\u30fc\u30c9\u5316\u5408\u7269\u306e\u767a\u898b\u3068\u3057\u3066\u91cd\u8981\u306a\u77e5\u898b\u3067\u3042\u308a\u3001\u5e73\u621026\u5e749\u6708\u306b\u7fa4\u99ac\u5927\u5b66\u3092\u51fa\u9858\u8005\u3068\u3057\u3066\u7279\u8a31\u3092\u53d6\u5f97\u3057\u305f\uff08\u7279\u8a31\u7b2c5610433\u53f7\uff09\u3002<\/p>\n<h3>2009\uff08\u5e73\u621021\u5e74\uff09<\/h3>\n<h4>\u30d9\u30fc\u30bf\u30bb\u30eb\u30ea\u30f3\u03b4\uff14\u53d7\u5bb9\u4f53\u53ca\u3073\u305d\u306e\u5229\u7528\uff08\u7279\u9858 2009-120182\uff09<\/h4>\n<p>\u5c0f\u5cf6\u81f3\uff08\u751f\u4f53\u8abf\u7bc0\u7814\u7a76\u6240\u30fb\u7d30\u80de\u8abf\u7bc0\uff09\u3001\u59b9\u5c3e\u660c\u6cbb\uff08\u5ca1\u5c71\u5927\u5b66\u5de5\u5b66\u90e8\uff09<\/p>\n<p>\u30d9\u30fc\u30bf\u30bb\u30eb\u30ea\u30f3\u03b4\uff14\u53d7\u5bb9\u4f53\u306f\u81b5\u03b2\u7d30\u80de\u304a\u3088\u3073\u305d\u306e\u524d\u99c6\u7d30\u80de\u306b\u767a\u73fe\u3059\u308b\u7d30\u80de\u819c\u53d7\u5bb9\u4f53\u3067\u3001\u30d9\u30fc\u30bf\u30bb\u30eb\u30ea\u30f3\u3084\u30d9\u30fc\u30bf\u30bb\u30eb\u30ea\u30f3\u03b4\uff14\u306e\u5206\u5316\u8a98\u5c0e\u4f5c\u7528\u3092\u4f1d\u9054\u3059\u308b\u3002\u305d\u306e\u6d3b\u6027\u5316\u306b\u3088\u308a\u3001\u03b2\u7d30\u80de\u306e\u5206\u5316\u3092\u4fc3\u9032\u3057\u3001\u03b2\u7d30\u80de\u91cf\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304b\u3089\u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642\u306b\u5f79\u7acb\u3064\u3068\u4e88\u60f3\u3055\u308c\u308b\u3002<\/p>\n<h3>2008\uff08\u5e73\u621020\u5e74\uff09<\/h3>\n<h4>\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u5264\uff08\u7279\u9858 2010-533883\uff09<br \/>\uff08\u56fd\u969b\u51fa\u9858PTC\/JP2009\/067561\u3001\u57fa\u790e\u51fa\u9858\u7279\u98582008-267852\uff09<\/h4>\n<p>\u5c0f\u5cf6\u81f3\uff08\u751f\u4f53\u8abf\u7bc0\u7814\u7a76\u6240\u30fb\u7d30\u80de\u8abf\u7bc0\uff09\u3001\u51b7\u725f\u7530\u9031\u4e00\uff08\u51fa\u5149\u8208\u7523\uff09\u3001\u4e2d\u5cf6\u5bff\u662d\uff08\u51fa\u5149\u8208\u7523\uff09\u3001\u6b66\u7530\u8302\u6a39\uff08\u7fa4\u99ac\u5927\u5b66\u5de5\u5b66\u90e8\uff09<\/p>\n<p>GPR119 \u306f\u81b5\u03b2\u7d30\u80de\u306b\u767a\u73fe\u3059\u308b GPCR \u3067\u3042\u308b\u304c\u3001\u3053\u306e\u53d7\u5bb9\u4f53\u3092\u6d3b\u6027\u5316\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4fc3\u9032\u3059\u308b\u5316\u5408\u7269\u306f\u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u6709\u7528\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n<h3>2004\uff08\u5e73\u621016\u5e74\uff09<\/h3>\n<h4>\u52d5\u8108\u786c\u5316\u4e88\u9632\u7269\u8cea\u3068\u305d\u306e\u5229\u7528\u6cd5\uff08\u7279\u98582004-279967\uff09<\/h4>\n<p>\u5ca1\u5cf6\u53f2\u548c\uff08\u751f\u4f53\u8abf\u7bc0\u7814\u7a76\u6240\u30fb\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u5206\u91ce\uff09\u3001\u4ec1\u79d1\u6df3\u826f\uff08\u7fa4\u99ac\u7523\u696d\u6280\u8853\u30bb\u30f3\u30bf\u30fc\uff09\u3001\u798f\u672c\u4eae\u5e73\uff08\u7fa4\u99ac\u7523\u696d\u6280\u8853\u30bb\u30f3\u30bf\u30fc\uff09\u3001\u95a2\u53e3\u662d\u535a\uff08\u7fa4\u99ac\u7523\u696d\u6280\u8853\u30bb\u30f3\u30bf\u30fc\uff09<\/p>\n<p>\u901a\u5e38\u98df\u7528\u306b\u7528\u3044\u308b\u30b3\u30f3\u30cb\u30e3\u30af\u30bc\u30ea\u30fc\u306f\u30b3\u30f3\u30cb\u30e3\u30af\u828b\u306e\u7cbe\u7c89\u304b\u3089\u30de\u30f3\u30ca\u30f3\u6210\u5206\u3092\u62bd\u51fa\u3057\u3066\u7528\u3044\u308b\u3002\u3053\u306e\u7cbe\u7c89\u3092\u4f5c\u308b\u904e\u7a0b\u3067\u5927\u91cf\u306e\u6b8b\u6e23\u304c\u7523\u696d\u5ec3\u68c4\u7269\uff08\u98db\u7c89\uff09\u3068\u3057\u3066\u751f\u3058\u308b\u3002\u672c\u7279\u8a31\u3067\u306f\u3053\u306e\u98db\u7c89\u304b\u3089\u8102\u8cea\u6210\u5206\u306b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u304a\u3051\u308b\uff36\uff23\uff21\uff2d\uff0d\uff11\u3001\uff29\uff23\uff21\uff2d\uff0d\uff11\u306a\u3069\u306e\u7d30\u80de\u63a5\u7740\u56e0\u5b50\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u6d3b\u6027\u3092\u898b\u51fa\u3057\u305f\u3002\u5185\u76ae\u7d30\u80de\u306b\u304a\u3051\u308b\u7d30\u80de\u63a5\u7740\u56e0\u5b50\u306e\u767a\u73fe\u6291\u5236\u306f\u52d5\u8108\u786c\u5316\u75c7\u306e\u767a\u75c7\u306b\u5bfe\u3057\u3066\u4e88\u9632\u7684\u306b\u50cd\u304f\u3068\u671f\u5f85\u3055\u308c\u308b\u3002<\/p>\n<h4>\u30b2\u30ce\u30e0DNA\u306e\u30e1\u30c1\u30eb\u5316\u691c\u51fa\u65b9\u6cd5 \u51fa\u9858 2004-226103 (2004\/08\/02)<\/h4>\n<p>\u767a\u660e\u8005 \u7551\u7530 \u51fa\u7a42<br \/>\u51fa\u9858\u4eba \u56fd\u7acb\u5927\u5b66\u6cd5\u4eba\u7fa4\u99ac\u5927\u5b66<\/p>\n<p>\u764c\u3092\u306f\u3058\u3081\u69d8\u3005\u306a\u75be\u60a3\u306b\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3001DNA\u30e1\u30c1\u30eb\u5316\u304c\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304b\u3089\u30b2\u30ce\u30e0\u5168\u4f53\u306b\u308f\u305f\u3063\u3066DNA\u30e1\u30c1\u30eb\u5316\u3092\u8abf\u3079\u308b\u3053\u3068\u306e\u91cd\u8981\u6027\u304c\u8a8d\u8b58\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u305d\u3053\u3067Microarray-based Integrated Analysis of Methylation by Isoschizomers (MIAMI)\u6cd5\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u65b9\u6cd5\u3067\u306fDNA\u30e1\u30c1\u30eb\u5316\u306e\u691c\u51fa\u306b\u5236\u9650\u9175\u7d20\u3092\u7528\u3044\u307e\u3059\u3002DNA\u306e\u30e1\u30c1\u30eb\u5316\u306f\u30b7\u30c8\u30b7\u30f3\u5869\u57fa\u306e\uff15\u306e\u4f4d\u7f6e\u3067\u8d77\u3053\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u307b\u3068\u3093\u3069\u304cCG\u3068\u3044\u3046\u914d\u5217\u306e\u30b7\u30c8\u30b7\u30f3\u306b\u96c6\u4e2d\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002Hpa II\u3068\u3044\u3046\u5236\u9650\u9175\u7d20\u306fCG\u3092\u542b\u3080CCGG\u3068\u3044\u3046\u914d\u5217\u3092\u8a8d\u8b58\u3057\u3066\u5207\u65ad\u3057\u307e\u3059\u304c\u3001\u5185\u5074\u306eC\u304c\u30e1\u30c1\u30eb\u5316\u3055\u308c\u3066\u3044\u308b\u3068DNA\u3092\u5207\u65ad\u3067\u304d\u307e\u305b\u3093(\u30e1\u30c1\u30eb\u5316\u611f\u53d7\u6027\u9175\u7d20\uff09 \u3002\u4e00\u65b9Hpa II\u3068\u540c\u3058CCGG\u914d\u5217\u3092\u8a8d\u8b58\u3059\u308b\u5236\u9650\u9175\u7d20\u306bMsp I\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u9175\u7d20\u306fHpa II\u3068\u7570\u306a\u308a\u5185\u5074\u306eC\u304c\u30e1\u30c1\u30eb\u5316\u3055\u308c\u3066\u3044\u3066\u3082\u3055\u308c\u3066\u3044\u306a\u304f\u3066\u3082DNA\u3092\u5207\u65ad\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059(\u30e1\u30c1\u30eb\u5316\u975e\u611f\u53d7\u6027\u9175\u7d20\uff09\u3002MIAMI\u6cd5\u3067\u306f\u3001\u6bd4\u8f03\u3059\u308b\u30b5\u30f3\u30d7\u30eb\u9593\u3067\uff08\uff11\uff09Hpa II\u306b\u3088\u308b\u5207\u308c\u5177\u5408\u306e\u5dee\u3068\u540c\u6642\u306b\uff08\uff12\uff09Msp I\u306b\u3088\u308b\u5207\u308c\u5177\u5408\u306e\u5dee\u3092\u6bd4\u8f03\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u30b5\u30f3\u30d7\u30eb\u9593\u306e\u30e1\u30c1\u30eb\u5316\u306e\u5dee\u3092\u691c\u51fa\u3057\u307e\u3059\u3002\uff08\uff11\uff09Hpa 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