Ayako Fukunaka (1, 2), Toshiyuki Fukada (3, 4), Jinhyuk Bhin (5)、Luka Suzuki (2), Takamasa Tsuzuki (6), Yuri Takamine (6), Bun-Ho Bin (4), Toshinori Yoshihara (6), Noriko Ichinoseki-Sekine (5), Hisashi Naito (5), Takeshi Miyatsuka (2), Shinzaburo Takamiya (7), Tsutomu Sasaki (8), Takeshi Inagaki (9), Tadahiro Kitamura (8), Shingo Kajimura (10), Hirotaka Watada (2), Yoshio Fujitani (1, 2 Corresponding Author） 1. Laboratory of Developmental Biology & Metabolism, IMCR, Gunma University 2. Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine 3. Faculty of Pharmaceutical Science, Diagnostic Sciences, School of Dentistry, Showa University 5. Department of Molecular Carcinogenesis, The Netherlands Cancer Institute 6. Graduate School of Health and Sports Science, Juntendo University 7. Department of Tropical Medicine and Parasitology, Graduate School of Medicine, Juntendo University 8. Laboratory of Metabolic Signaling, IMCR, Gunma University 9. Laboratory of Epigenetics and Metabolism, IMCR, Gunma University 10. UCSF Diabetes Center and Department of Cell and Tissue Biology, University of California San Francisco
About
Our team has been investigating roles of zinc homeostasis in health and disease of endocrine organs by focusing on biological function of zinc transporters. Genetic mutations in ZIP13, a member of zinc transporter family, are known to reduce adipose tissue mass in humans; however, the underlying mechanisms remains unknown. Here, we demonstrate that the Zip13-deficient mouse shows enhanced beige adipocyte biogenesis and energy expenditure, and thus shows ameliorated diet-induced obesity and insulin resistance. Our studies showed that an accumulation of the CCAAT/enhancer binding protein-β (C/EBP-β) protein is essential for the enhanced adipocyte browning caused by the loss of ZIP13. Given that recent studies demonstrated that adult human brown adipocytes share biological characteristics with mouse beige adipocytes, the results of our study may contribute significantly to the development of new therapies for obesity and metabolic syndrome even in human.
Paper information
Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression. Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y PLoS Genet. 2017 Aug 30;13(8):e1006950. doi: 10.1371/journal.pgen.1006950. eCollection 2017 Aug. PMID: 28854265
Online URL
https://www.ncbi.nlm.nih.gov/pubmed/28854265
