Hara T1,2, Maejima I1, Akuzawa T1, Hirai R1, Kobayashi H1, Tsukamoto S3, Tsunoda M1, Ono A2, Yamakoshi S2, Oikawa S2, Sato K1. 1. Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan. 2. Laboratory of Cellular Regulation, Faculty of Human Sciences, Waseda University, Mikajima, Tokorozawa, Saitama, Japan. 3. Laboratory Animal and Genome Sciences Section, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Anagawa, Inage-ku, Chiba, Japan.
Rer1 not only functions as a ER retrieval receptor for various membrane proteins including ER membrane proteins, immature and misfolded membrane proteins but also plays a role in the early-Golgi quality control system for unassembled components of membrane protein complexes such as -secretase complex. In this study, we find that Rer1 is required for a sufficient expression of g-secretase complex on the cell surface, which regulates Notch signaling for neural stem cell maintenance during mouse cerebral cortex development.
Rer1-mediated quality control system is required for neural stem cell maintenance during cerebral cortex development. HaraT, Maejima I, Akuzawa T, Hirai R, Kobayashi H, Tsukamoto S, Tsunoda M, Ono A, Yamakoshi S, Oikawa S, Sato K. PLoS Genet. 2018 Sep 27;14(9):e1007647. doi: 10.1371/journal.pgen.1007647. eCollection 2018 Sep. PMID: 30260951