Associate Professor：Koichi Sato
Assistant Professor: Yoshio Hoshiba
Research Fellow: Norimitsu Suzuki
Assistant Technician: Wakana Mizutani
Assistant Technician: Junko Sugi
Drug discovery in neuropsychiatry has been limited to chemical modifications of compounds originally discovered serendipitously. Therefore, more mechanism-oriented strategies of drug discovery for neuropsychiatric disorders are awaited. The deterioration of the neuronal circuit has attracted attention as the pathophysiology of these disorders, and aberrant responses against the stress, such as oxidative stress, is now being considered as a possible causal signaling in these diseases. Thus, we aim to elucidate the disease-relevant signaling pathway by utilizing state-of-art imaging technique, eventually challenging to identify a novel therapeutic target for neuropsychiatric disorders.
- Project#1 Examination of neuronal stress response for the drug discovery of neuropsychiatric disorders.
- Project#2 Visualization of the disease-relevant neurocircuits in the neuropsychiatric model mice.
- Project#3 Molecular and cellular mechanism of comorbidity neuropsychiatry disorders and diabetes mellitus.
Neuropsychiatric disorders, Multi-organ circle ring, Neurocircuits, Synapse, Optogenetics, 2-photon imaging
- Hoshiba Y, Wada T, Hayashi-Takagi A. (2017) Front Neural Circuits 11, 1-12.
- Shirai F, Hayashi-Takagi A. (2017) Psychiatry Clin Neurosci (In press).
- Hayashi-Takagi A. (2017) Neurosci Res 114, 3-8.
- Hayashi-Takagi A. et al. (2015) Nature 525(7569):333-8.
- Hayashi-Takagi A. et al. (2014) Proc Natl Acad Sci USA 111(17):6461-6.