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群馬大学 生体調節研究所

アクセス

Integrated Signaling Systems

Professor:Tohru Ishitani
ishitani*gunma-u.ac.jp
(*=@)
Lab website
http://signal-system.imcr.gunma-u.ac.jp/

Member

Professor: Tohru Ishitani
Assistant Professor: Chihiro Mogi
Assistant Professor: Masayuki Oginuma
Specially Appointed Assistant Professor: Shizuka Ishitani
Research Fellow: Kota Abe
Graduate Student : Shohei Ogamino
Assistant Technician: Eri Tomiuka
Assistant Technician: Yukiko Miyazaki
Guest Research Fellow: Yuki Akieda
Guest Research Fellow: Yukinari Haraoka
Guest Research Fellow: Zou Juqi

Research

In our body, cells recognize its position and roles via cell-cell communication and behave appropriately. Such cell behavior supports tissue morphogenesis and homeostasis, and its dysregulation is involved in a variety of diseases, including cancer and diabetes. We investigate the molecular basis of cell-cell communication and behavior in animal body, using in vivo imaging, molecular genetics, molecular and cell biology, and biochemistry.

On-going projects

  1. Cell competition and its roles in animal development and cancer.
  2. Aging Research using small fishes
  3. Function and regulation of nemo-like kinase (NLK) in cancer, metabolic diseases, and neurodegenerative disease.
  4. Mechanisms that regulate Wnt signaling in tissue morphogenesis and homeostasis.

 

Keywords

Degenerative Disease, Aging mechanism, Developmental robustness, in vivo imaging, zebrafish, short-lived killifish, Morphogen, Cell competition, Cancer, Development of therapeutic drugs

Select References

  1. Shimizu N. et al. (2014) Cell Reports 8(5): 1391-404
  2. Ota S. et al. (2012) EMBO Journal 31(8): 1904-15
  3. Shimizu N. et al. (2012) Developmental Biology 370(1): 71-85
  4. Ishitani S et al. (2011) Molecular Biology of the Cell 22(2): 266-77
  5. Ishitani T et al., (2010) Nature Cell Biology 12(3): 278-85

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