Professor: Tohru Ishitani
Assistant Professor: Chihiro Mogi
Graduate Student : Shohei Ogamino
In our body, cells recognize its position and roles via cell-cell communication and behave appropriately. Such cell behavior supports tissue morphogenesis and homeostasis, and its dysregulation is involved in a variety of diseases, including cancer and diabetes. We investigate the molecular basis of cell-cell communication and behavior in animal body, using in vivo imaging, molecular genetics, molecular and cell biology, and biochemistry.
- Cell competition and its roles in animal development and cancer.
- Aging Research using small fishes
- Function and regulation of nemo-like kinase (NLK) in cancer, metabolic diseases, and neurodegenerative disease.
- Mechanisms that regulate Wnt signaling in tissue morphogenesis and homeostasis.
Degenerative Disease, Aging mechanism, Developmental robustness, in vivo imaging, zebrafish, short-lived killifish, Morphogen, Cell competition, Cancer, Development of therapeutic drugs
1. Akieda Y. et al. Nature Commun. (2019)10: 4710
2. Abe K. et al. Cell Rep. (2019) 27:928-939
3. Shimizu N. et al. (2014) Cell Reports 8(5): 1391-404
4. Ota S. et al. (2012) EMBO Journal 31(8): 1904-15
5. Shimizu N. et al. (2012) Developmental Biology 370(1): 71-85
6. Ishitani S et al. (2011) Molecular Biology of the Cell 22(2): 266-77
7. Ishitani T et al., (2010) Nature Cell Biology 12(3): 278-85