Member
Professor: SATO Ken
Associate Professor: SATOUH Yuhkoh
Assistant Professor: MAJIMA Ikuko
Postdoctoral Fellow: KAWASAKI Ichiro
Postdoctoral Fellow: HIRAI Rika
JSPS Research Fellow: SUGIURA Kenta
Technical Assistant: AKUZAWA Tomoko
Graduate Student: SUTO Shunichi
Graduate Student: MICHIZAKI Mamoru
Research
Membrane trafficking plays essential roles not only in secretion and nutrient uptake but also in various physiological processes such as those involving the endocrine system, metabolic system, and nervous system in animals. In our laboratory, we study the molecular mechanisms and physiological functions of membrane trafficking in multicellular organisms by using the nematode Caenorhabditis elegans and mice as model systems. In addition, we study the molecular mechanisms underlying protein-misfolding diseases, in which abnormal membrane proteins accumulate in the endoplasmic reticulum (ER), in order to discover new targets for the treatment of such diseases.
On-going projects
- Analysis of molecular mechanisms underlying low-density lipoprotein trafficking in C. elegans
- Analysis of physiological functions of membrane trafficking during development
- Analysis of the molecular mechanisms underlying ER retention of disease-associated membrane proteins
Keywords
Membrane trafficking, Secretion, Metabolism, Development, C. elegans, Mouse, Fertilization, Autophagy, Mitochondria, Endoplasmic reticulum
Select References
- Morita A. et al. (2021) Development. 148(14):dev199461
- Kunii M. et al. (2021) J Cell Biol. 220(1):e201910080
- Yamamoto YH. et al. (2020) J Cell Biol. 219(8):e201903127
- Umeda R. et al. (2020) Nat Commun. 11(1):1606
- Saegusa K. et al. (2018) J. Cell Biol. 217(6):2073-2085
- Sato M. et al. (2018) Nature Cell Bilol. 20(1):81-91
- Sakaguchi A. et al. (2015) Dev. Cell. 35(2):211-21
- Hara T. et al. (2014) Sci Rep. 4:6992
- Saegusa K. et al. (2014) Mol Biol Cell. 25(20):3095-104
- Sato M. et al. (2014) Development. 141(6):1324-31
- Sato M. and Sato K. (2011) Science. 334(6059):1141-4
