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群馬大学 生体調節研究所

アクセス

Molecular Genetics

Professor:Takayuki Yamashita
y-taka*gunma-u.ac.jp
(*=@)
Lab website
http://molgen.imcr.gunma-u.ac.jp

 

Member

Professor: Takayuki Yamashita
Assistant Professor: Tsukasa Oda
Assistant Professor: Takayuki Sekimoto
Research Fellow: Kiminori Kurashima
Assitant Technician: Kyoko Tomizawa
MD-phD course student: Satoko Sunaga
MD-phD course student: Yuya Itagaki
Graduate Student: Ruri Nakamura
Graduate Student: Miyako Matsuda
Graduate Student: Masumi Ohata

Research

Biomolecules such as DNA and protein suffer from constant damage from various environmental agents and cellular metabolites. How cells respond to these stresses has a critical role in determination of cells’ fate: senescence (irreversible growth arrest), death or transformation into cancer; and cellular sensitivity to various drugs. Our aim is to clarify the molecular mechanisms of these cellular responses to genotoxic and proteotoxic stresses, understanding the pathological mechanisms and developing innovative diagnostics and therapeutics.

図1

On-going projects

  1. Cellular responses to oncogene-induced DNA replication stress
  2. Regulation of cellular senescence by the heat shock response mediator HSF1
  3. Role of DNA translesion synthesis polymerases in cellular sensitivity to anti-tumor drugs

Keywords

DNA damage, Replication stress, Translesion synthesis polymerase, Genomic instability, Heat shock response, Cell senescence

Select References

  1. Sekimoto T. et al. (2015) Mol Cell Biol. 35; 4; 699-715.
  2. Pozo FM. et al. (2011)  Mol Cell Biol.  31; 16; 3396-3409.
  3. Sekimoto T. et al. (2010) Mol Cell. 37; 1; 79-89.

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