• /

群馬大学 生体調節研究所

アクセス

Medical Neuroscience

Hayashi

Professor:Akiko Hayashi-Takagi
hayashitakagi*gunma-u.ac.jp
(*=@)
Lab website
medical-neuro.imcr.gunma-u.ac.jp

 

 

 

 

Member

Professor:Akiko Hayashi-Takagi
Associate Professor:Koichi Sato
Assistant Professor: Yoshio Hoshiba
Lab Manager: Mayumi Nakamura
Research Fellow: Norimitsu Suzuki
Research Fellow: Takeyoshi Wada
Research Fellow: Yousuke Kitahara (JSPS, PD)
Assistant Technician: Kaori Takahashi
Assistant Technician: Yumiko Kondo
Assistant Technician: Wakana Mizutani
Assistant Technician: Mari Kawada
Assistant Technician: Emi Hosoya
Graduate Student (D4): Fukutoshi Shirai (JSPS, DC2)
Graduate Student (D1): Kisho Obi
Undergraduate Student (Md-PhD course): Takayuki Imai
Undergraduate Student (Md-PhD course): Mari Umezawa
Undergraduate Student (Md-PhD course): Akito Hiraga
Undergraduate Student (Md-PhD course): Masayasu Sato

Research

Drug discovery in neuropsychiatry has been limited to chemical modifications of compounds originally discovered serendipitously. Therefore, more mechanism-oriented strategies of drug discovery for neuropsychiatric disorders are awaited. The deterioration of the neuronal circuit has attracted attention as the pathophysiology of these disorders, and aberrant responses against the stress, such as oxidative stress, is now being considered as a possible causal signaling in these diseases. Thus, we aim to elucidate the disease-relevant signaling pathway by utilizing state-of-art imaging technique, eventually challenging to identify a novel therapeutic target for neuropsychiatric disorders.

On-going projects

  • Project#1 Examination of neuronal stress response for the drug discovery of neuropsychiatric disorders.
  • Project#2 Visualization of the disease-relevant neurocircuits in the neuropsychiatric model mice.
  • Project#3 Molecular and cellular mechanism of comorbidity neuropsychiatry disorders and diabetes mellitus.

 

Keywords

Neuropsychiatric disorders, Multi-organ circle ring, Neurocircuits, Synapse, Optogenetics, 2-photon imaging

Select References

1.Hoshiba Y, Wada T, Hayashi-Takagi A. (2017) Front Neural Circuits 11, 1-12.
2.Shirai F, Hayashi-Takagi A. (2017) Psychiatry Clin Neurosci (In press).
3.Hayashi-Takagi A. (2017) Neurosci Res 114, 3-8.
4.Hayashi-Takagi A. et al. (2015) Nature 525(7569):333-8.
5.Hayashi-Takagi A. et al. (2014) Proc Natl Acad Sci USA 111(17):6461-6.

PAGE TOP