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群馬大学 生体調節研究所

アクセス

Molecular Traffic

佐藤健写真

Professor:Ken Sato
sato-ken*gunma-u.ac.jp
(*=@)
Lab Homepage
http://traffic.dept.med.gunma-u.ac.jp/

Member

Professor: Ken Sato
Assistant Professor:Nobukatsu Morooka
Technical Officer: Hisae Kobayashi
Research Fellow: Ikuko Maejima
Research Fellow: Yasuharu Kushida
Assistant Technician: Rika Hirai
Assistant Technician: Tomoko Akuzawa
Assistant Technician: Mayumi Seto
Graduate Student: Keiko Saegusa
Graduate Student: Ryosuke Konuma
Graduate Student: Akihito Morita
Medical Student (MD-phD course): Yuki Shibusawa
Medical Student (MD-phD course): Takehiro Nakamura
Medical Student(MD-phD course): Inoya Isobe

Research

Membrane trafficking plays essential roles not only in secretion and nutrient uptake but also in various physiological processes such as those involving the endocrine system, metabolic system, and nervous system in animals. In our laboratory, we study the molecular mechanisms and physiological functions of membrane trafficking in multicellular organisms by using the nematode Caenorhabditis elegans and mice as model systems. In addition, we study the molecular mechanisms underlying protein-misfolding diseases, in which abnormal membrane proteins accumulate in the endoplasmic reticulum (ER), in order to discover new targets for the treatment of such diseases.

moltra en

 

On-going projects

  1. Analysis of molecular mechanisms underlying low-density lipoprotein trafficking in C. elegans
  2. Analysis of physiological functions of membrane trafficking during development
  3. Analysis of the molecular mechanisms underlying ER retention of disease-associated membrane proteins

Keywords

Membrane trafficking, Secretion, Metabolism, Development, C. elegans, Mouse, Fertilization, Autophagy, Mitochondria, Endoplasmic reticulum

Select References

1.Sakaguchi et al. (2015)  Dev. Cell. 35(2):211-21.
2.Hara T. et al. (2014)  Sci Rep. 11;4:6992.
3.Saegusa K. et al. (2014)  Mol Biol Cell.  15;25(20):3095-104.
4.Sato M. et al. (2014)  Development  141(6):1324-31.
5.Sato M. and Sato K. (2011)  Science 334(6059):1141-4.

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