Assistant Professor: TAKAINE Masakatsu
masaktakaine*gunma-u.ac.jp
(*=@)
Lab website
https://www.giar.gunma-u.ac.jp/program/program_takaine/
Member
Assistant Professor : Masakatsu Takaine
Research
Cells are constantly exposed to various stimuli such as environmental stress and nutrient sources, and if they cannot respond appropriately to such external stimuli, they will be damaged, leading to aging or cell death. Therefore, a detailed understanding of the cell response mechanism is necessary for the development of treatments for lifestyle-related diseases and aging.
Using the budding yeast Saccharomyces cerevisiae, which is an ideal eukaryotic cell model, we would like to clarify the molecular mechanism by which cells maintain homeostasis of energy metabolism while responding to various environmental changes.
On-going projects
- ATP homeostasis and cellular ageing
- Visualization of intracellular ATP dynamics
- Granule-like assembly of de novo purine metabolic enzymes
- Cell death and cellular GTP level
Keywords
yeast, metabolism, signal transduction, ATP, energy metabolism, purine metabolism, TOR complex
Select References
- Hoshino S. et al., (2021) Commun. Biol. 4(1)
- Takaine M. et al., (2019) J Cell Sci. 132(8)
- Ito H. et al., (2019) BBRC 511(4)
