• /

群馬大学 生体調節研究所

アクセス

Secretion Biology

torii

Associate Professor:Seiji Torii
storii*gunma-u.ac.jp
(*=@)
Lab website
http://secret-biol.imcr.gunma-u.ac.jp/page1/page1.html

 

Member

Associate Professor: Seiji Torii
JSPS Research Fellow: Chisato Kubota
Graduate Student: Ryosuke Shintoku
Joint Associate Professor: Nobukazu Nameki
Joint Associate Professor: Keiichi Yamada
Joint Associate Professor: Hiroaki Horiuchi
Joint Associate Professor: Toshitada Yoshihara
Joint Research Fellow: Yoshiki Kaneko
Joint Research Fellow: Tomomi Fujisawa

Research

Aims: To elucidate formation mechanisms for highly integrated functions of differentiated cells such as pancreatic beta-cells and neuronal cells with use of molecular and cellular technical approaches. Research: We investigate the biosynthesis and secretion of peptide hormones, and the regulation of cell survival and death of neuroendocrine cells to understand fundamental mechanisms on a variety of human diseases. We are also developing new chemical compounds or fluorescent/luminescent probes to directly image cellular functions and pathological states of diseases such as cancer, diabetes, and ischemia.

ホームページ用(分泌制御)2016 英語

 

 

 

 

 

 

 

On-going projects

  1. Study on regulated growth, survival, and cell death in pancreatic beta-cells and neuronal cells.
  2. Mechanisms of peptide hormones secretion and secretory granule formation in endocrine cells.
  3. Development of fluorescent or luminescent probes for investigating various diseases.

Keywords

Insulin, Secretory granules, Membrane transport, Necrosis, Reactive oxygen species, Protein-tyrosine phosphatase, Anti-cancer reagent, Lysosome, Islet, Hypoxia

Select References

  1. Torii S, et al. (2016)  Biochem J 473: 769-777
  2. Gomi H, et al. (2015)  J Histochem Cytochem 63: 350-66
  3. Sun M, et al. (2013)  Traffic 14: 205-218
  4. Hou N, et al. (2012)  PLoS One 7: e47921
  5. Saito N, et al. (2011)  Traffic 12: 499-506
  6. Kubota C, et al. (2010)  J Biol Chem 285: 667-674

 

PAGE TOP