Associate Professor：Seiji Torii
Associate Professor: Seiji Torii
JSPS Research Fellow: Chisato Kubota
Graduate Student: Ryosuke Shintoku
Joint Associate Professor: Nobukazu Nameki
Joint Associate Professor: Keiichi Yamada
Joint Associate Professor: Hiroaki Horiuchi
Joint Associate Professor: Toshitada Yoshihara
Joint Research Fellow: Yoshiki Kaneko
Joint Research Fellow: Tomomi Fujisawa
Aims: To elucidate formation mechanisms for highly integrated functions of differentiated cells such as pancreatic beta-cells and neuronal cells with use of molecular and cellular technical approaches. Research: We investigate the biosynthesis and secretion of peptide hormones, and the regulation of cell survival and death of neuroendocrine cells to understand fundamental mechanisms on a variety of human diseases. We are also developing new chemical compounds or fluorescent/luminescent probes to directly image cellular functions and pathological states of diseases such as cancer, diabetes, and ischemia.
- Study on regulated growth, survival, and cell death in pancreatic beta-cells and neuronal cells.
- Mechanisms of peptide hormones secretion and secretory granule formation in endocrine cells.
- Development of fluorescent or luminescent probes for investigating various diseases.
Insulin, Secretory granules, Membrane transport, Necrosis, Reactive oxygen species, Protein-tyrosine phosphatase, Anti-cancer reagent, Lysosome, Islet, Hypoxia
- Torii S, et al. (2016) Biochem J 473: 769-777
- Gomi H, et al. (2015) J Histochem Cytochem 63: 350-66
- Sun M, et al. (2013) Traffic 14: 205-218
- Hou N, et al. (2012) PLoS One 7: e47921
- Saito N, et al. (2011) Traffic 12: 499-506
- Kubota C, et al. (2010) J Biol Chem 285: 667-674