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群馬大学 生体調節研究所

アクセス

Integrated Signaling Systems

Professor:Tohru Ishitani
ishitani*gunma-u.ac.jp
(*=@)
Lab website
http://signal-system.imcr.gunma-u.ac.jp/

Member

Professor: Tohru Ishitani
Assistant Professor: Chihiro Mogi
Research fellow: Shizuka Ishitani
Research Fellow: Yuki Akieda
Assistant Technician: Shohei Ogamino

Research

In our body, cells recognize its position and roles via cell-cell communication and behave appropriately. Such cell behavior supports tissue morphogenesis and homeostasis, and its dysregulation is involved in a variety of diseases, including cancer and diabetes. We investigate the molecular basis of cell-cell communication and behavior in animal body, using in vivo imaging, molecular genetics, molecular and cell biology, and biochemistry.

On-going projects

  1. Cell competition and its roles in animal development and cancer.
  2. Mechanisms that regulate Wnt signaling in tissue morphogenesis and homeostasis.
  3. Function and regulation of nemo-like kinase (NLK) in cancer, metabolic diseases, and neurodegenerative disease.
  4. Application of Fish as a model for human disease.

Keywords

Intracellular and intercellular signal transduction, in vivo imaging, morphogen, Robustness in development, Cell competition, Cancer, Neurodegenerative disease, Disease model

Select References

  1. Shimizu N. et al. (2014) Cell Reports 8(5): 1391-404
  2. Ota S. et al. (2012) EMBO Journal 31(8): 1904-15
  3. Shimizu N. et al. (2012) Developmental Biology 370(1): 71-85
  4. Ishitani S et al. (2011) Molecular Biology of the Cell 22(2): 266-77
  5. Ishitani T et al., (2010) Nature Cell Biology 12(3): 278-85

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