Professor: Tohru Ishitani
Assistant Professor: Chihiro Mogi
Research fellow: Shizuka Ishitani
Research Fellow: Yuki Akieda
Assistant Technician: Shohei Ogamino
In our body, cells recognize its position and roles via cell-cell communication and behave appropriately. Such cell behavior supports tissue morphogenesis and homeostasis, and its dysregulation is involved in a variety of diseases, including cancer and diabetes. We investigate the molecular basis of cell-cell communication and behavior in animal body, using in vivo imaging, molecular genetics, molecular and cell biology, and biochemistry.
- Cell competition and its roles in animal development and cancer.
- Mechanisms that regulate Wnt signaling in tissue morphogenesis and homeostasis.
- Function and regulation of nemo-like kinase (NLK) in cancer, metabolic diseases, and neurodegenerative disease.
- Application of Fish as a model for human disease.
Intracellular and intercellular signal transduction, in vivo imaging, morphogen, Robustness in development, Cell competition, Cancer, Neurodegenerative disease, Disease model
- Shimizu N. et al. (2014) Cell Reports 8(5): 1391-404
- Ota S. et al. (2012) EMBO Journal 31(8): 1904-15
- Shimizu N. et al. (2012) Developmental Biology 370(1): 71-85
- Ishitani S et al. (2011) Molecular Biology of the Cell 22(2): 266-77
- Ishitani T et al., (2010) Nature Cell Biology 12(3): 278-85