Professor: FUJITANI Yohio
fujitani*gunma-u.ac.jp
(*=@)
Lab website
http://tou-taisha.imcr.gunma-u.ac.jp/
Member
Professor: FUJITANI Yoshio
Associate Professor: SATO Takashi
Assistant Professor: FUKUNAKA Ayako
Assistant Professor: NAKAGAWA Yuko
Technical Assistant: SUDA Asuka
Technical Assistant: TAMURA Yasuko
Technical Assistant: MIZUTANI Wakana
Technical Assistant: ISHIZAKA Tomomi
Graduate Student: SHIMADA Masaharu
Research
The dysfunction of pancreatic b cells and brown adipocytes can cause diabetes and metabolic syndrome. Our goal is to elucidate the molecular mechanism involved in the maintenance of homeostasis of these higher-order function cells, which is the key to glucose metabolism. We aim to elucidate the mechanism of cellular homeostasis, from a variety of viewpoints, including developmental biology, zinc biology, and autophagy by effectively utilizing genetically engineered mice. Furthermore, using our findings from basic medical research, we aim to establish a groundbreaking treatment for diabetes and obesity.
On-going projects
- Research on the developmental biology of pancreatic b cells
- Analysis of zinc transporters involved in the browning of adipocytes
- Analysis of a new type of pancreatic cancer arising from islets
Keywords
diabetes, glucose metabolism, developmental biology, pancreatic b cells, genetically engineered mice, brown adipocytes, zinc biology, pancreatic cancer
Select References
- Fukaishi T. et al. (2021) Diabetologia 64(12):2803-2816
- Perez-Frances M. et al. (2021) Nat Commun.12(1):4458.
- Hara A.et al. (2019) Endocr J. 66(5):459-68
- Fukunaka A.et al.(2017) Plos Genet. 13(8):e1006950
- Shigihara N. et al. (2014) J Clin Invest. 124(8):3634-44.
